Infection, Persistence & Clearance of Oral HPV in Women

感染、持续性

• 批准号: 7094953
• 负责人: JIMMY T EFIRD
• 金额: $ 13.63万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7094953
• 关键词: clinical research; infection; neoplasm /cancer

DESCRIPTION (provided by applicant): In contrast to the anogenital area, where the persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human papillomavirus (HPV) infection in the oral cavity of women. HPV is spread in a non-hematogenous fashion without a viremic phase, and is believed to occur in the oral cavity in measurable amounts as a consequence of persistent cross-infection or auto- inoculation with genital HPV types. Given the histologic similarity between the anogenital and oral cavity regions, the continuous presence of high-risk HPV types in the oral cavity is likely a strong marker for progression of intraepithelial disease in certain areas of the oral cavity. However, convincing evidence in support of this premise remains elusive in the literature. Even in the case of basaloid-type tumors of the tonsillar region, which have been the focus of several studies in recent years, other factors may underlie increased oral HPV rates in affected individuals. These include impaired immunity consequent of the extended cancer process or treatment, and cancer-related bias in sampling and detection of the virus. The major goal of this proposal is to characterize etiologic determinants of infection, clearance and persistence of HPV infection in the oral cavity. This will be accomplished by conducting secondary analysis of data previously collected through the National Institute of Allergy and Infectious Disease's Women's Interagency HIV Study (WIHS) program and the intraepithelial dysplasia clinic at the University of California, San Francisco. Similar to the anogenital region, HPV-related disease in the oral cavity may be preventable with appropriate screening and knowledge of risk factors for this infection in women. The underlying strength of the proposed analyses over previously published studies is the opportunity to answer important questions on the temporal interrelation of oral, cervical and anal HPV infection and natural history, since within-person data was concurrently collected at each of these sites. Extensive individual epidemiologic and behavioral risk factor information is available for detailed analysis in this large dataset. Knowledge gained from this study will provide important information about the role of HPV in oral disease, help explain inconsistencies in results from earlier HPV oral studies, which were constrained by size and exposure data, and aid public health response in intervention and education.

描述（由申请人提供）：与肛门生殖器区域相反，其中人乳头瘤病毒（HPV）的持续存在是大多数宫颈上皮内瘤变和癌症发展的重要先决条件，目前对女性口腔中人乳头瘤病毒（HPV）感染的感染、持续存在或清除知之甚少。HPV以非血源性方式传播而没有病毒血症期，并且据信由于持续交叉感染或自身接种生殖器HPV类型而以可测量的量在口腔中发生。鉴于肛门生殖器和口腔区域之间的组织学相似性，口腔中持续存在高危HPV类型可能是口腔某些区域上皮内疾病进展的强烈标志。然而，令人信服的证据支持这一前提仍然难以捉摸的文献。即使在扁桃体区域的基底细胞型肿瘤的情况下，近年来一直是几项研究的重点，其他因素可能是受影响个体口腔HPV率增加的基础。这些包括因癌症过程或治疗延长而导致的免疫力受损，以及病毒采样和检测中与癌症相关的偏倚。该提案的主要目标是描述口腔中HPV感染的感染、清除和持续性的病因决定因素。这将通过对先前通过国家过敏和传染病研究所的妇女机构间HIV研究（WIHS）计划和加州大学弗朗西斯科分校的上皮内异型增生诊所收集的数据进行二次分析来完成。与肛门生殖器区域类似，口腔中的HPV相关疾病可以通过适当的筛查和对女性感染风险因素的了解来预防。与先前发表的研究相比，拟议分析的潜在优势是有机会回答关于口腔、宫颈和肛门HPV感染与自然史的时间相关性的重要问题，因为在这些研究中心同时收集了人内数据。广泛的个人流行病学和行为风险因素信息可用于在这个大型数据集中进行详细分析。从这项研究中获得的知识将提供有关HPV在口腔疾病中作用的重要信息，有助于解释早期HPV口腔研究结果的不一致性，这些研究受到规模和暴露数据的限制，并有助于干预和教育中的公共卫生反应。