Training in the Genome Sciences and the Hemoglobinopathies

描述：参见说明。记下申请的广泛、长期目标和具体目标，并参考与健康有关的 项目（即，与机构工作计划的相关性）。简要描述研究设计和实现这些目标的方法。 the rationality原理andtechniques技术youwill use to pursuit追求these goals目标. 另外，用两三句话，用通俗的语言描述这项研究与公共卫生的相关性。如果申请得到资助， 这样的描述将成为公开信息。因此，请勿包含专有/机密信息。请勿超过空间 提供了，â。. .¿_^__ 杜克大学-北卡罗来纳州查佩尔山大学的总体目标（北）培训 基因组科学和血红蛋白病项目旨在培训一批国内和 “外国博士后研究员是杰出的调查基础和治疗的 血红蛋白病使用基因组学和相关的大规模和高通量方法， 基因组科学每个受训者选择的研究领域是否是基因组学。蛋白质组学或 计算生物学和一个人未来的研究是否是基础，翻译！或临床，每个研究员将 有望获得广泛而全面的理解基因组科学应用于正在进行的 血红蛋白病的研究项目实现这一目标的培训将通过以下方式进行： 课程;基因组学，蛋白质组学和计算实验室的广泛轮换;每周 有基因组科学研究人员参加的学术讨论会;有积极计划的研究实验室 遗传病研究;以及通过培训具有基因组和遗传学专业知识的教师进行共同指导 科学和血红蛋白病，以发展对多学科的充分认识， 这是培训计划的本质。 培训计划将由杜克基因组科学研究所所长和 政策和杜克大学综合镰状细胞中心主任。杰出的研究员将 从申请人中确定了强大的池现有的博士后培训机会在杜克 和UNG在血液学、输血医学、医学基因组学、血管疾病和基因组学方面的研究 科学;从申请人到杜克和杜克大学的个人导师;以及由 由坦桑尼亚和泰国的同事和合作者组成的国际咨询小组。研究 机会将由一组超过25名杜克和杜克大学的教师提供，他们具有以下方面的专业知识： 基因组科学和血红蛋白病。 我们将培养一批国内外同行，致力于推动我们的发展。 了解和治疗血红蛋白病。这一调查人员网络将构成以下方面的基础： 一系列的国际合作来减轻这些疾病的痛苦和负担。 绩效等级（组织、城市、等级） 北卡罗来纳州，达勒姆，杜克大学 北卡罗来纳州，查佩尔山，北卡罗来纳州 PHS 398（Raw. 09/04）第2页表格页a 03/03/06 11：40传真@]004 Kirschstein-NRSA初始预算校长晚宴。W）黄藤（Jiardi HuntingtonF.） 期间替换页<La 8 t|“"* mlddte） 通过

DESCRIPTION: Seeinstructions. Stele the application's broad, long-term objectives andspecific aims, making reference to trie health relatednoss of the project (l.e,, relevanceto the mlaslon of the agency). Describe concisely the research design and methods for achieving these goals.Describe the rationale andtechniques youwill useto pursue these goals. in addition, In two or three sentences, describe In plain, lay language the relevance of this research to public health. If the application is funded, this description, as is, will become public Information. Therefore, do not Include proprietary/confidential Information. DO NOT EXCEEDTHE SPACE PROVIDED. , ¿ . . .¿ _^__ the overall goal of the Duke University - University of North Carolina at Chapel Hill (UNC) Training Program in the Genome Sciences and the HemogloblnopathiesIs to train a cohort of both domestic and 'foreign postdoctoralfellows to be outstanding investigators of the basis for and treatment of the herhoglobinbpathies. using genomlcs and related large-scale and high-throughput approaches in the genome sciences. Whether each trainee's chosen area of focus Is in genomics. proteomics or computational biology and whether one's future research is basic, translations! or clinical, each fellow will be expected to gain a broad and comprehensiveunderstandingof the genome sciences as applied to ongoing research projects In the hemoglobinopathies. Training towards this goal will be achievedthrough: advanced coursework; extensive rotations in genomics, proteomics, and computational laboratories; a weekly colloquium involving researchers in the genome sciences; researchin laboratories with active programs In herhbglbbihopathy research; and co-mentoring by training faculty with expertise both in the genome sciences and in the hemoglobinopathies in order to develop a full appreciation for the multidlsciplinary nature1of this training prograrn. The training programwill be directedjointly by the Director of the Duke Institute for Genome Sciences& Policy and by the Director of the Duke-UNC Comprehensive Sickle Cell Center. Outstandingfellows will be identified from among a strong pool of applicants to existing postdoctoral training opportunities at both Duke and UNG in hematology, transfusion medicine, medical genomics, vascular disease and the genome sciences; from applicantsto Individual mentorsat Duke and UNC; and from applicants identified by an international advisorygroup consisting of colleagues and collaboratorsin Tanzania and Thailand. Research opportunities will be providedby a group of more than 25 Duke and UNC faculty members with expertise in the genome sciences and in the hemoglobinopathies. We will develop a group of domestic andforeign colleagues who are dedicated to advance our understanding and treatment of the hemoglobinopathies. This network of investigators will form the basis for an ongoing series of internationalcollaborationsto reducethe pain and burden of these disorders. PERFORMANCE SlTE(S) (organization, city, slate) Duke Uhiversity, Durham, North Carolina University of North Carolina, Chapel Hill, North Carolina PHS 398 (Raw. 09/04) Page 2 Form Pagea 03/03/06 11:40FAX @]004 Kirschstein-NRSA Initial Budget PrincipalinmagMfngrm Dinner. W)jiardi HuntingtonF. Period Substitute Page <La8t| ""*¿mlddte) THROUGH