Training in the Genome Sciences and the Hemoglobinopathies

基因组科学和血红蛋白病培训

• 批准号: 7871508
• 负责人: Huntington F Willard
• 金额: $ 19.91万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2012-01-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7871508
• 关键词: Area; Clinical; Collaborations; Computational Biology; Disease; Faculty; Future; Genome; Genomics; Goals; Hematology; Hemoglobinopathies; Individual; Institutes; International; Laboratories; Medical; Medicine; Mentors; Nature; North Carolina; Pain; Postdoctoral Fellow; Proteomics; Research; Research Personnel; Research Project Grants; Rotation; Science; Science Policy; Series; Sickle Cell; Tanzania; Thailand; Training; Training Programs; Transfusion; Universities; Vascular Diseases; base; cohort; member; multidisciplinary; post-doctoral training; programs

DESCRIPTION (provided by applicant): The overall goal of the Duke University - University of North Carolina at Chapel Hill (UNC) Training Program in the Genome Sciences and the Hemoglobinopathies is to train a cohort of both domestic and foreign postdoctoral fellows to be outstanding investigators of the basis for and treatment of the hemoglobinopathies, using genomics and related large-scale and high-throughput approaches in the genome sciences. Whether each trainee's chosen area of focus is in genomics, proteomics or computational biology and whether one's future research is basic, translational or clinical, each fellow will be expected to gain a broad and comprehensive understanding of the genome sciences as applied to ongoing research projects in the hemoglobinopathies. Training towards this goal will be achieved through: advanced coursework; extensive rotations in genomics, proteomics, and computational laboratories; a weekly colloquium involving researchers in the genome sciences; research in laboratories with active programs in hemoglobinopathy research; and co-mentoring by training faculty with expertise both in the genome sciences and in the hemoglobinopathies in order to develop a full appreciation for the multidisciplinary nature of this training program. The training program will be directed jointly by the Director of the Duke Institute for Genome Sciences & Policy and by the Director of the Duke-UNC Comprehensive Sickle Cell Center. Outstanding fellows will be identified from among a strong pool of applicants to existing postdoctoral training opportunities at both Duke and UNC in hematology, transfusion medicine, medical genomics, vascular disease and the genome sciences; from applicants to individual mentors at Duke and UNC; and from applicants identified by an international advisory group consisting of colleagues and collaborators in Tanzania and Thailand. Research opportunities will be provided by a group of more than 25 Duke and UNC faculty members with expertise in the genome sciences and in the hemoglobinopathies. We will develop a group of domestic and foreign colleagues who are dedicated to advance our understanding and treatment of the hemoglobinopathies. This network of investigators will form the basis for an ongoing series of international collaborations to reduce the pain and burden of these disorders.

描述（申请人提供）：杜克大学-北卡罗来纳州大学查佩尔山（查珀尔山）基因组科学和血红蛋白病培训项目的总体目标是培养一批国内外博士后研究员，使其成为使用基因组学和基因组科学中相关的大规模和高通量方法研究血红蛋白病的基础和治疗的杰出研究者。无论每个学员选择的重点领域是基因组学，蛋白质组学或计算生物学，以及未来的研究是否是基础，转化或临床，每个研究员都将有望获得对基因组科学的广泛和全面的了解，并将其应用于正在进行的血红蛋白病研究项目。实现这一目标的培训将通过：高级课程;基因组学，蛋白质组学和计算实验室的广泛轮换;涉及基因组科学研究人员的每周座谈会;在血红蛋白病研究的积极计划实验室的研究;和共通过在基因组科学和血红蛋白病方面具有专业知识的培训教师进行指导，以充分认识多学科这个培训项目的性质。该培训计划将由杜克基因组科学与政策研究所所长和杜克大学综合镰状细胞中心主任共同指导。优秀的研究员将从申请人中确定现有的博士后培训机会在杜克和血液学，输血医学，医学基因组学，血管疾病和基因组科学的强大的游泳池;从申请人到个人导师在杜克和剑桥;并从由同事和合作者在坦桑尼亚和泰国组成的国际咨询小组确定的申请人。研究机会将由一组超过25名杜克和杜克大学的教师提供，他们在基因组科学和血红蛋白病方面具有专业知识。我们将培养一批致力于提高我们对血红蛋白病的认识和治疗的国内外同事。这一研究者网络将为正在进行的一系列国际合作奠定基础，以减少这些疾病的疼痛和负担。

项目成果

Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance.

• DOI: 10.1016/j.chom.2012.06.007
• 发表时间: 2012-08-16
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: LaMonte G;Philip N;Reardon J;Lacsina JR;Majoros W;Chapman L;Thornburg CD;Telen MJ;Ohler U;Nicchitta CV;Haystead T;Chi JT
• 通讯作者: Chi JT