Training in the Genome Sciences and the Hemoglobinopathies

描述(由申请人提供)：杜克大学-北卡罗来纳大学教堂山分校(UNC)基因组科学和血红蛋白病培训计划的总体目标是利用基因组学和基因组科学中相关的大规模和高通量方法，培养一批国内外博士后研究员，成为血红蛋白病基础和治疗的杰出研究人员。无论每个学员选择的重点领域是基因组学、蛋白质组学还是计算生物学，无论一个人未来的研究是基础研究、翻译研究还是临床研究，每个研究员都将被期望对应用于正在进行的血红蛋白疾病研究项目的基因组科学有一个广泛而全面的了解。实现这一目标的培训将通过以下方式实现：高级课程；基因组学、蛋白质组学和计算实验室的广泛轮换；基因组科学研究人员每周一次的座谈会；在有积极计划的实验室进行研究；通过培训拥有基因组科学和血红蛋白病专业知识的教师进行共同指导，以充分认识这一培训计划的多学科性质。培训计划将由杜克大学基因组科学与政策研究所所长和杜克-北卡罗来纳大学综合镰刀细胞中心主任联合指导。优秀的研究员将从杜克大学和北卡罗来纳大学现有的血液学、输血医学、医学基因组学、血管疾病和基因组科学博士后培训机会的强大申请者库中挑选出来；从杜克大学和北卡罗来纳大学的申请者到个人导师；以及从由坦桑尼亚和泰国的同事和合作者组成的国际咨询小组确定的申请者中挑选。杜克大学和北卡罗来纳大学的25多名教职员工将提供研究机会，这些教职员工在基因组科学和血红蛋白疾病方面具有专业知识。我们将培养一批致力于提高我们对血红蛋白疾病的认识和治疗的国内外同行。这一调查网络将构成正在进行的一系列国际合作的基础，以减轻这些疾病的痛苦和负担。

DESCRIPTION (provided by applicant): The overall goal of the Duke University - University of North Carolina at Chapel Hill (UNC) Training Program in the Genome Sciences and the Hemoglobinopathies is to train a cohort of both domestic and foreign postdoctoral fellows to be outstanding investigators of the basis for and treatment of the hemoglobinopathies, using genomics and related large-scale and high-throughput approaches in the genome sciences. Whether each trainee's chosen area of focus is in genomics, proteomics or computational biology and whether one's future research is basic, translational or clinical, each fellow will be expected to gain a broad and comprehensive understanding of the genome sciences as applied to ongoing research projects in the hemoglobinopathies. Training towards this goal will be achieved through: advanced coursework; extensive rotations in genomics, proteomics, and computational laboratories; a weekly colloquium involving researchers in the genome sciences; research in laboratories with active programs in hemoglobinopathy research; and co-mentoring by training faculty with expertise both in the genome sciences and in the hemoglobinopathies in order to develop a full appreciation for the multidisciplinary nature of this training program. The training program will be directed jointly by the Director of the Duke Institute for Genome Sciences & Policy and by the Director of the Duke-UNC Comprehensive Sickle Cell Center. Outstanding fellows will be identified from among a strong pool of applicants to existing postdoctoral training opportunities at both Duke and UNC in hematology, transfusion medicine, medical genomics, vascular disease and the genome sciences; from applicants to individual mentors at Duke and UNC; and from applicants identified by an international advisory group consisting of colleagues and collaborators in Tanzania and Thailand. Research opportunities will be provided by a group of more than 25 Duke and UNC faculty members with expertise in the genome sciences and in the hemoglobinopathies. We will develop a group of domestic and foreign colleagues who are dedicated to advance our understanding and treatment of the hemoglobinopathies. This network of investigators will form the basis for an ongoing series of international collaborations to reduce the pain and burden of these disorders.