Training in the Genome Sciences and the Hemoglobinopathies

描述（由申请人提供）：杜克大学-北卡罗来纳大学教堂山分校（UNC）基因组科学和血红蛋白病培训项目的总体目标是培养一批国内外博士后，利用基因组学和相关的大规模和高通量方法，成为血红蛋白病基础和治疗的杰出研究者。无论每个学员选择的重点领域是基因组学、蛋白质组学还是计算生物学，无论他们未来的研究是基础研究、转化研究还是临床研究，每个学员都将被期望获得广泛而全面的基因组科学理解，并应用于正在进行的血红蛋白病研究项目。实现这一目标的培训将通过以下方式实现：高级课程；在基因组学、蛋白质组学和计算实验室广泛轮换；每周一次的由基因组科学研究人员参加的讨论会；开展血红蛋白病研究项目的实验室研究；由具有基因组科学和血红蛋白病专业知识的培训教员共同指导以便充分认识到这个培训项目的多学科性质。该培训项目将由杜克大学基因组科学与政策研究所主任和杜克大学-北卡罗来纳大学综合镰状细胞中心主任共同指导。将从杜克大学和北卡罗来纳大学现有的血液学、输血医学、医学基因组学、血管疾病和基因组科学博士后培训机会的大量申请者中选出优秀的研究员；从申请人到杜克大学和北卡罗来纳大学的个人导师；以及由坦桑尼亚和泰国的同事和合作者组成的国际咨询小组确定的申请人。研究机会将由超过25名杜克大学和北卡罗来纳大学的教师组成，他们在基因组科学和血红蛋白病方面具有专业知识。我们将培养一批致力于提高我们对血红蛋白病的认识和治疗的国内外同行。这一研究人员网络将构成一系列正在进行的国际合作的基础，以减少这些疾病的痛苦和负担。

DESCRIPTION (provided by applicant): The overall goal of the Duke University - University of North Carolina at Chapel Hill (UNC) Training Program in the Genome Sciences and the Hemoglobinopathies is to train a cohort of both domestic and foreign postdoctoral fellows to be outstanding investigators of the basis for and treatment of the hemoglobinopathies, using genomics and related large-scale and high-throughput approaches in the genome sciences. Whether each trainee's chosen area of focus is in genomics, proteomics or computational biology and whether one's future research is basic, translational or clinical, each fellow will be expected to gain a broad and comprehensive understanding of the genome sciences as applied to ongoing research projects in the hemoglobinopathies. Training towards this goal will be achieved through: advanced coursework; extensive rotations in genomics, proteomics, and computational laboratories; a weekly colloquium involving researchers in the genome sciences; research in laboratories with active programs in hemoglobinopathy research; and co-mentoring by training faculty with expertise both in the genome sciences and in the hemoglobinopathies in order to develop a full appreciation for the multidisciplinary nature of this training program. The training program will be directed jointly by the Director of the Duke Institute for Genome Sciences & Policy and by the Director of the Duke-UNC Comprehensive Sickle Cell Center. Outstanding fellows will be identified from among a strong pool of applicants to existing postdoctoral training opportunities at both Duke and UNC in hematology, transfusion medicine, medical genomics, vascular disease and the genome sciences; from applicants to individual mentors at Duke and UNC; and from applicants identified by an international advisory group consisting of colleagues and collaborators in Tanzania and Thailand. Research opportunities will be provided by a group of more than 25 Duke and UNC faculty members with expertise in the genome sciences and in the hemoglobinopathies. We will develop a group of domestic and foreign colleagues who are dedicated to advance our understanding and treatment of the hemoglobinopathies. This network of investigators will form the basis for an ongoing series of international collaborations to reduce the pain and burden of these disorders.