NIMH Center for Collaborative Genetic Studies

NIMH 合作遗传学研究中心

• 批准号: 7127704
• 负责人: JAY Arnold TISCHFIELD
• 金额: $ 645.42万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127704
• 关键词: Internet; behavioral /social science research tag; behavioral genetics; bioinformatics; biomedical facility; cell line; cooperative study; data management; family genetics; functional /structural genomics; genetic mapping; genotype; health science research analysis /evaluation; health science research support; lymphoblast; mental disorders; meta analysis; tissue /cell preparation; tissue resource /registry

DESCRIPTION (provided by applicant): This proposal is driven by the need to find genes that contribute to the etiology of mental disorders; a goal more readily attained if clinical data and biological materials (DNA and cell lines) are openly shared among investigators. During the past four years, the NIMH Center for Genetic Studies (NCGS), established over 13,000 lymphoblast cell lines (LCLs) from blood samples and processed clinical and genotype data submitted by PIs of the NIMH Human Genetics Initiative. The NCGS distributed over 20,000 DNA aliquots and made more than 82 distributions of family, clinical and genotype data to a larger group of investigators. The establishment of these resources has played a critical role in enhancing and invigorating research on the genetics of mental disorders. Drs. Tischfield and Rice propose to continue their NCGS efforts with this application to become the Cooperative Agreement Award-funded (U24) "Center for Collaborative Genetic Studies on Mental Disorders" (the "Center"), submitted in response to RFA MH-03-003. They will continue to produce LCLs as a renewable source of DNA and will maintain an improved and easily accessible, web-based bioinformatics repository of clinical and genotype data that will drive future research. They also propose analyses of shared, public data sets that will add to their predictive value for gene discovery. The Center will provide consultation on project design (e.g., power studies), detailed genomics of candidate regions, blood (or other biologicals) collection, data analysis, and best organization and use of shared resources. The overriding aim of the Center will be to serve the scientific needs of the NIMH PIs, while respecting subject confidentiality, informed consent issues, and PI prerogatives. By encouraging and facilitating the collection and sharing of biologicals as well as clinical and genotype data from subjects or families with mental disorders such as schizophrenia, bipolar disorder, or autism, and its own analyses of these data, the Center will greatly accelerate progress toward understanding the inherited components in the etiology of these diseases.

描述（由申请人提供）：该提案是由寻找有助于精神障碍病因的基因的必要性驱动的；如果研究人员公开共享临床数据和生物材料（DNA和细胞系），则更容易实现的目标。在过去的四年中，NIMH遗传学研究中心（NCG）从血液样本中建立了13,000多个淋巴细胞细胞系（LCLS），并通过NIMH人类遗传学计划的PIS提交的临床和基因型数据处理。 NCG分配了超过20,000个DNA等分试样，并向较大的研究者制作了82多个家庭，临床和基因型数据。这些资源的建立在增强和振奋精神障碍遗传学研究方面发挥了关键作用。博士。 Tischfield和Rice提议继续将其NCGS努力通过此申请继续成为合作协议奖学金（U24）“精神疾病合作研究中心”（“中心”），以响应RFA MH-03-003。他们将继续生产LCL作为DNA的可再生能源，并将维护改进且易于访问的基于网络的临床和基因型数据的生物信息学存储库，以推动未来的研究。他们还建议对共享的公共数据集进行分析，以增加其基因发现的预测价值。该中心将提供有关项目设计（例如电力研究），候选区域的详细基因组，血液（或其他生物学）收集，数据分析以及最佳组织和共享资源使用的咨询。该中心的重大目标是满足NIMH PI的科学需求，同时尊重主题机密，知情同意问题和PI特权。通过鼓励和促进生物学的收集和共享以及来自精神分裂症，双相情感障碍或自闭症等精神疾病的受试者或患有精神疾病的家庭的临床和基因型数据，以及其对这些数据的分析，该中心将大大加速这些疾病学遗传学成分的进步。