NIMH Center for Collaborative Genetic Studies

描述（由申请人提供）：NIMH遗传学计划是由了解精神障碍（如精神分裂症、双相情感障碍、抑郁症和自闭症）的遗传（遗传）、环境和生理原因的需要驱动的。如果许多研究人员共享从大队列或家庭中受影响和未受影响个体的血液中产生的注释临床数据和生物材料（即DNA， RNA，血浆蛋白和细胞系），则最容易实现这一目标。为此，NIMH建立了一个生产和储存生物材料和相关临床数据的中心资源。根据美国国立卫生研究院的数据共享政策，这个资源，目前被称为NIMH精神障碍协同遗传研究中心（“中心”），已经将这些生物样本和临床数据分发给了大量调查精神障碍原因的合格研究人员。我们自1998年9月以来一直维持该中心，期间向该中心提交了70,797份血液样本，其中包括自2003年7月以来前所未有的52,578份样本。由于技术的改进，中心已经将提交的血液样本加工成淋巴母细胞系达到了前所未有的99.7%的成功率。自2003年7月以来，该中心已分发了306,423份DNA样本和4,006个淋巴母细胞系，并向约300名心理健康研究人员分发了400多份临床和遗传数据。这些分布资源的范围和质量使精神健康遗传学领域能够更好地理解精神障碍的生物学。在此，我们建议继续作为精神障碍基因组研究中心。生物制剂中心将继续从血液和细胞系中生产和分发可再生的生物研究资源。数据管理和基因组学核心将继续改进基于网络的临床和基因型数据存储库以及相关的生物信息学和计算基因组学工具。分析核心将产生旨在整合和分析大型、独立的遗传和临床数据集的方法。该中心的首要目标是继续以灵活和创新的方式满足NIMH和其他精神卫生研究人员的科学需求，同时尊重人类受试者的机密性、知情同意问题和个人权利。

DESCRIPTION (provided by applicant): The NIMH Genetics Initiative is driven by the need to understand the inherited (genetic), environmental and physiologic causes of mental disorders, such as schizophrenia, bipolar disorder, depression, and autism. This goal will be most readily attained if annotated clinical data and biological materials (i.e., DNA, RNA, plasma proteins, and cell lines) produced from the blood of affected and unaffected individuals in large cohorts or families are shared among many researchers. To this end, the NIMH has established a central resource for producing and banking biological materials and associated clinical data. Per NIH data sharing policies, this resource, currently known as the NIMH Center for Collaborative Genetic Studies of Mental Disorders ("the Center"), has distributed these biological samples and clinical data to a large number of qualified researchers investigating the causes of mental disorders. We have maintained the Center since September 1998, during which 70,797 blood samples were submitted to the Center, including an unprecedented 52,578 samples since July 2003. Due to technical improvements the Center has processed submitted blood samples into lymphoblast cell lines with an unprecedented 99.7% success. Since July 2003, the Center has distributed 306,423 DNA samples and 4,006 lymphoblast cell lines, and made more than 400 distributions of clinical and genetic data to ~300 mental health researchers. The scope and quality of these distributed resources have empowered the field of mental health genetics to produce a better understanding of the biology of mental disorders. Herein, we propose to continue as the Center for Genomic Studies on Mental Disorders. The Biologics Core will continue to produce and distribute renewable biologic research resources from blood and cell lines. The Data Management and Genomics Core will continue improvements to the web-based repository of clinical and genotype data and associated bioinformatics and computational genomics tools. The Analysis Core will produce methodology designed to integrate and analyze large, independent sets of genetic and clinical data. The overriding aim of the Center is to continue to serve the scientific needs of NIMH and other mental health researchers in a flexible and innovative manner while respecting human subject confidentiality, informed consent issues, and PI prerogatives.