(NEURO)TOXICOGENOMICS AND CHILD HEALTH

（神经）毒理基因组学和儿童健康

• 批准号: 7266679
• 负责人: Peter S Spencer
• 金额: $ 76.97万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7266679
• 关键词: DNA damage; environmental toxicology; health; neurotoxicology

DESCRIPTION (provided by applicant) This is an application to become a Member of the NIEHS Toxicogenomics Research Consortium. The application originates from the synergistic fusion of two components of the Oregon Health Sciences University (OHSU), the resulting entity working in close cooperation with the Massachusetts General Hospital (MGH) at Harvard University. Leadership of this research program and the Toxicology Research Core Project (TRCP) is located in the OHSU Center for Research on Occupational and Environmental Toxicology (CROET), a dedicated research institute with strength in cellular, animal and human toxicology, with an emphasis on neurotoxicology. Co-leadership of this proposal is located in the nearby OHSU School of Medicine Department of Pediatrics which, together with participation from the Division of Medical Informatics and the Department of Medical and Molecular Genetics, brings strength in genomics, proteomics and bioinformatics, with emphasis on the developing brain and child health. Core Cl combines these components to support the toxicogenomics research needs of the TRCP and the Research Projects, PI-P3. Project 1 examines growth factor signaling in neural cells and its modulation by the neurotoxic anti-cancer drug taxol. Project 2 investigates early and late effects of genotoxic agents on neural development. Project 3, a subcontract with MGH, determines if neural and glial cells, as well as cells from different genetic strains, have overlapping or distinct patterns of toxicant-induced changes in gene expression that affect specific cellular functions, such as migration and division. The OHSU-MGH collaboration further strengthens this application by pooling our respective ongoing toxicogenomics studies and building an interdependent relationship for the benefit of the Consortium. Additionally, the participation in this proposal of scientific leaders of the NIEHS-funded Superfund Basic Research Center (SBRC) at OHSU (located in CROET) will ensure that the benefits of TRC membership are rapidly spread to other NIEHS-supported investigators at CROET and its collaborating SBRC institutions in the Pacific Northwest.

描述（由申请人提供） 这是申请成为NIEHS毒理基因组学研究的成员 财团该应用程序源于两个协同融合 组成部分的俄勒冈州健康科学大学（OHSU），由此产生的 与马萨诸塞州总医院密切合作的实体 (MGH)在哈佛大学。领导这项研究计划和 毒理学研究核心项目（TRCP）位于OHSU中心， 职业和环境毒理学研究（CROET），一个专门的 在细胞、动物和人类毒理学方面具有实力的研究机构， 重点是神经毒理学该提案的共同领导人是 位于附近的OHSU医学院儿科系， 与医学信息学分部和 医学和分子遗传学系，带来了基因组学的力量， 蛋白质组学和生物信息学，重点是发育中的大脑和儿童 健康Core Cl结合这些成分来支持毒理基因组学 TRCP和研究项目的研究需求，PI-P3。项目1 检查神经细胞中的生长因子信号传导及其由 神经毒性抗癌药紫杉醇。项目2早调查晚调查 遗传毒性物质对神经发育的影响。项目3，a 与MGH，确定是否神经和神经胶质细胞，以及细胞从 不同的遗传菌株，具有重叠或不同的毒性诱导模式， 影响特定细胞功能的基因表达变化， 例如移徙和分裂。OHSU-MGH合作进一步 通过汇集我们各自正在进行的毒理基因组学， 研究和建立相互依存的关系， 财团此外，参与这项科学建议， OHSU的NIEHS资助的超级基金基础研究中心（SBRC）的领导人 （设在CROET）将确保迅速获得真相与和解委员会成员的利益， 传播到其他NIEHS支持的研究人员在CROET和其合作 太平洋西北部的SBRC机构。

项目成果

Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC.

据 ALS-PDC 报道，苏铁基因毒素甲基偶氮甲醇会破坏大脑泛素蛋白酶体通路、Tau 蛋白和 α-突触核蛋白。

• DOI: 10.1093/jnen/nlab006
• 发表时间: 2021
• 期刊: Journal of neuropathology and experimental neurology
• 影响因子: 3.2
• 作者: Kisby,GlenE;Eriksen,JasonL;Chlebowski,AnnaC;Spencer,PeterS
• 通讯作者: Spencer,PeterS

Does the cycad genotoxin MAM implicated in Guam ALS-PDC induce disease-relevant changes in mouse brain that includes olfaction?

关岛 ALS-PDC 中涉及的苏铁基因毒素 MAM 是否会引起小鼠大脑中与疾病相关的变化（包括嗅觉）？

• DOI: 10.4161/cib.17603
• 发表时间: 2011
• 期刊: Communicative & integrative biology
• 作者: Kisby,Glen;Palmer,Valerie;Lasarev,Mike;Fry,Rebecca;Iordanov,Mihail;Magun,Eli;Samson,Leona;Spencer,Peter
• 通讯作者: Spencer,Peter