(NEURO)TOXICOGENOMICS AND CHILD HEALTH

描述（由申请人提供） 这是成为 NIEHS 毒理学研究会员的申请 财团。该应用源于两种技术的协同融合 俄勒冈健康科学大学 (OHSU) 的组成部分， 与马萨诸塞州总医院密切合作的实体 （麻省总医院）哈佛大学。该研究计划的领导和 毒理学研究核心项目 (TRCP) 位于 OHSU 中心 职业与环境毒理学研究 (CROET) 具有细胞、动物和人体毒理学实力的研究所， 重点是神经毒理学。该提案的共同领导者是 位于附近的 OHSU 医学院儿科， 医学信息学部和 医学和分子遗传学系，带来基因组学方面的优势， 蛋白质组学和生物信息学，重点是大脑和儿童的发育 健康。 Core Cl 结合了这些组件来支持毒物基因组学 TRCP 和研究项目 PI-P3 的研究需求。项目1 检查神经细胞中的生长因子信号传导及其调节 神经毒性抗癌药物紫杉醇。项目2调查早期和晚期 遗传毒性物质对神经发育的影响。项目3、分包合同 与 MGH 一起，确定神经细胞和神经胶质细胞以及来自 不同的遗传菌株，具有重叠或不同的毒物诱导模式 影响特定细胞功能的基因表达变化， 比如迁移和分裂。 OHSU-MGH 进一步合作 通过汇集我们各自正在进行的毒物基因组学来加强这一应用 研究并建立相互依存的关系，以造福于 财团。此外，参与本提案的科学 NIEHS 资助的 OHSU 超级基金基础研究中心 (SBRC) 的领导 （位于CROET）将确保TRC会员的好处迅速得到实现 传播到 CROET 及其合作机构的其他 NIEHS 支持的研究人员 太平洋西北地区的 SBRC 机构。

DESCRIPTION (provided by applicant) This is an application to become a Member of the NIEHS Toxicogenomics Research Consortium. The application originates from the synergistic fusion of two components of the Oregon Health Sciences University (OHSU), the resulting entity working in close cooperation with the Massachusetts General Hospital (MGH) at Harvard University. Leadership of this research program and the Toxicology Research Core Project (TRCP) is located in the OHSU Center for Research on Occupational and Environmental Toxicology (CROET), a dedicated research institute with strength in cellular, animal and human toxicology, with an emphasis on neurotoxicology. Co-leadership of this proposal is located in the nearby OHSU School of Medicine Department of Pediatrics which, together with participation from the Division of Medical Informatics and the Department of Medical and Molecular Genetics, brings strength in genomics, proteomics and bioinformatics, with emphasis on the developing brain and child health. Core Cl combines these components to support the toxicogenomics research needs of the TRCP and the Research Projects, PI-P3. Project 1 examines growth factor signaling in neural cells and its modulation by the neurotoxic anti-cancer drug taxol. Project 2 investigates early and late effects of genotoxic agents on neural development. Project 3, a subcontract with MGH, determines if neural and glial cells, as well as cells from different genetic strains, have overlapping or distinct patterns of toxicant-induced changes in gene expression that affect specific cellular functions, such as migration and division. The OHSU-MGH collaboration further strengthens this application by pooling our respective ongoing toxicogenomics studies and building an interdependent relationship for the benefit of the Consortium. Additionally, the participation in this proposal of scientific leaders of the NIEHS-funded Superfund Basic Research Center (SBRC) at OHSU (located in CROET) will ensure that the benefits of TRC membership are rapidly spread to other NIEHS-supported investigators at CROET and its collaborating SBRC institutions in the Pacific Northwest.