Center of Excellence in Environmental Toxicology

家长奖：总体：摘要 这是完成的环境健康科学核心中心(EHS)的第三个竞争性续展 宾夕法尼亚大学(宾夕法尼亚大学)环境毒理学卓越中心(CEET)。 主任是Trevor M.Penning博士(Thelma Brown和Henry Charles Molinoff教授 药理学)，副主任是丽贝卡·A·西蒙斯医学博士(#年的Hallam Hurt特聘教授 儿科)。该中心由来自18个部门和5所学校的71名成员组成，成员人数几乎相等 来自佩雷尔曼医学院(PSOM)的基础和临床医生-科学家代表和 费城儿童医院(CHOP)。中东欧在#年建立了机构、区域和国家身份。 在没有公共卫生学院和环境健康科学系的情况下，环境健康科学(EHS) 宾夕法尼亚。CEET中基础和临床医生-科学家的协同组合促进了翻译 解决基本问题并将知识转化为行动的环境健康研究 对人类健康和疾病有重大影响，符合NIEHS战略计划。CEET使命 就是“阐明环境暴露和人类疾病之间的机械联系，以及 将调查结果转化为行动，以改善弱势个人以及地方、国家和 全球社区“。这一使命是通过五个目标完成的。在目标1中：我们使用灵活的主题 区域结构，开展环境健康转化研究，提高精准公众健康水平。我们的 目前的主题是空气污染与肺部健康；环境暴露与癌症；窗口-- 敏感性；以及环境神经科学。每个主题领域都融合了支柱或曝光科学， 不良结果构建(路径和网络)解释现象组并将其翻译到社区 和人类受试者。目标2：我们与东南亚和西北地区的社区进行双向沟通。 宾夕法尼亚州，并利用社区参与来制定CEET的研究议程。目标3：我们提供 促进精准公共卫生的设施核心结构。我们的综合健康科学设施核心是熟练的 在人类受试者研究设计和提供人群暴露服务中，使用制图模型， 地理信息系统工具和生物传感器。在我们的翻译生物标记核心中测量暴露和影响的生物标记 它以其他地方难以效仿的精密度和准确度进行质谱分析。 Exposure Biology Informatics Core将计算、机器学习和人工智能的力量带到 预测未知因素的毒性，并整合大数据集以识别“组学”数据中的模式并预测 不利的结果。目标4：我们通过资助以下试点项目建设环境健康科学能力 早期调查人员(ESI)和第一次进行环境健康研究的高级调查人员 时间到了。目标5：我们通过变革性的环境健康科学家支持培养ESI的职业生涯 提供指导、拨款提案审查、环境健康和设施核心研讨会的计划。

Parent award: OVERALL : ABSTRACT This is the third competing continuation for an accomplished Environmental Health Sciences Core Center (EHS CC), The Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania (Penn). The Director is Trevor M. Penning, PhD (The Thelma Brown and Henry Charles Molinoff Professor of Pharmacology) and the Deputy Director is Rebecca A. Simmons, MD (The Hallam Hurt Endowed Professor in Pediatrics). The Center is comprised of 71 members from 18 Departments and 5 Schools, with almost equal representation of basic and clinician-scientists drawn from the Perelman School of Medicine (PSOM) and Children’s Hospital of Philadelphia (CHOP). The CEET has built an institutional, regional and national identity in environmental health sciences (EHS) in the absence of a School of Public Health and Department of EHS at Penn. The synergistic combination of basic and clinician-scientists within the CEET promotes translational environmental health research that addresses fundamental questions and translates knowledge into action to have a major impact on human health and disease consistent with the NIEHS Strategic Plan. The CEET mission is to “elucidate the mechanistic links between environmental exposures and human disease, and translate findings into action to improve the health of vulnerable individuals, and local, national, and global communities”. This mission is accomplished through five aims. In Aim 1: We use a flexible thematic area structure to conduct translational environmental health research to improve precision public health. Our current themes are in Air Pollution & Lung Health; Environmental Exposures & Cancer; Windows-of- Susceptibility; and Environmental Neuroscience. Each thematic area integrates the pillars or exposure science, adverse outcome constructs (pathways and networks) to explain the phenome with translation to communities and human subjects. In Aim 2: We conduct bi-directional communication with communities in S.E and N.E. Pennsylvania and use community engagement to set the research agenda for the CEET. In Aim 3: We provide a facility core structure to promote precision public health. Our Integrative Health Sciences Facility Core is adept in human subject study design and in conducting population exposure services, using cartographic modeling, GIS tools and biosensors. Biomarkers of exposure and effect are measured in our Translational Biomarker Core which conducts mass spectrometric assays at a level of precision and accuracy difficult to emulate elsewhere. The Exposure Biology Informatics Core brings to bear the power of computation, machine learning and AI to predict the toxicity of unknowns and integrate Big-data sets to recognize patterns in “omics” data and predict adverse outcomes. In Aim 4: We build capacity in environmental health sciences by funding pilot projects to Early Stage Investigators (ESI) and to senior investigators conducting environmental health research for the first time. In Aim 5: We cultivate the careers of ESI through a transformative Environmental Health Scientist Support Program that provides mentoring, grant proposal review, environmental health and Facility Core workshops.