SNRP AT HUNTER COLLEGE

亨特学院的 SNRP

• 批准号: 7241027
• 负责人: Marie T. Filbin
• 金额: $ 5.73万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7241027
• 关键词: cooperative study; developmental neurobiology; science education

The long-term goal of this proposal is to create a strong Neuroscience Research Program at Hunter College by bringing together a core of Neuroscientists whose research focus is the general theme of "Repairing the Damaged Nervous System", The planned core of molecular/cellular Neurobiologists will have similar, and highly complimentary interests in such key health-related areas as neuronal death and survival, axonal regeneration and guidance during development, and myelination, during both development and after disease or injury. By developing the theme of nervous system repair, the current Neuroscience strengths at Hunter College will be expanded. The first aim of the proposal is to strengthen the research of two junior investigators already at Hunter, Dr. Vanya Quinones and Dr. Jesus Angulo, to the point where independent funding can be expected. Released time from teaching will allow these two researchers the time to develop their work and, equally important, to foster their planned collaboration and mentoring with established, well- funded, successful scientists. Through these collaborations, the young investigators will learn not only new techniques but also how to accumulate appropriate preliminary data for an independent proposal. Finally, to assure their research development, internal and external advisory committees will monitor the progress and long-term research goals for these two junior investigators. A key feature of the proposed Neuroscience Program stems from the complementary work between the research proposals of the two junior PIs and one submitted by the PD, Dr. Marie T. Filbin, which will bring two exciting new technologies to Hunter: an animal model of spinal cord regeneration and viral vector delivery of foreign cDNAs to primary cells in culture and in vivo. Funding of this proposal will also establish a seminar series in Neuroscience to foster communication between the Neuroscience Program and outside researchers. A strong Neuroscience Research Program will also (a) present Neuroscience to undergraduates at an early stage in their career to help stimulate their interest in this crucial field and (b) provide a wider choice in Neuroscience for graduate students doing their doctoral research. An integrated Neuroscience Program can generate new ideas, expose researchers to a variety of state-of-the-art techniques, and attract strong post-doctoral fellows. It is anticipated that at least two additional young Neuroscience faculty will be recruited to the Program on the general theme "Repairing the Damaged Nervous System".

这项提议的长期目标是在亨特学院创建一个强大的神经科学研究计划，通过聚集一群神经科学家的核心，他们的研究重点是“修复受损的神经系统”，计划中的核心分子/细胞神经生物学家将在发育期间和疾病或损伤后的神经元死亡和存活、发育过程中的轴突再生和指导以及髓鞘形成等与健康相关的关键领域拥有类似的高度互补的兴趣。通过开发神经系统修复的主题，亨特学院目前的神经科学优势将得到扩大。该提案的第一个目的是加强已经在亨特的两名初级调查人员--万娅·奎诺内斯博士和杰西·安古洛博士--的研究，以期获得独立的资金。从教学中释放出来的时间将使这两位研究人员有时间发展他们的工作，同样重要的是，促进他们与成熟的、资金充足的、成功的科学家进行有计划的合作和指导。通过这些合作，年轻的研究人员不仅将学习新的技术，而且还将学习如何为独立的提案积累适当的初步数据。最后，为了确保他们的研究进展，内部和外部咨询委员会将监督这两名初级调查人员的进展和长期研究目标。拟议的神经科学计划的一个主要特点源于两个初级PI的研究提案和PD提交的一个研究提案之间的互补性工作，这将为Hunter带来两项令人兴奋的新技术：脊髓再生的动物模型和将外来cDNA运送到培养和体内原代细胞的病毒载体。这项提案的资金还将在神经科学方面建立一个研讨会系列，以促进神经科学计划与外部研究人员之间的交流。强大的神经科学研究计划还将：(A)在本科生职业生涯的早期阶段向他们介绍神经科学，以帮助激发他们对这一关键领域的兴趣；(B)为从事博士研究的研究生提供更广泛的神经科学选择。一个综合的神经科学项目可以产生新的想法，让研究人员接触到各种最先进的技术，并吸引强大的博士后研究员。预计将至少再招聘两名年轻的神经科学教员参加以“修复受损的神经系统”为总主题的计划。