Support for Enhancement Excellence in Research at UPR-RP

描述(由申请人提供)：本补充申请要求在波多黎各大学里约热内卢分校的SCORE计划中增加四个新项目。包括三个来自生物系的项目和一个来自化学的项目。一份来自生物学(Maldonado)的申请和另一份来自化学(Rodriguez)的申请是根据我们分数申请摘要中报告的评论修改后的申请。另一份报告来自最近聘用的微生物学家(多明格斯)，另一份报告来自参与上一轮赠款周期的一名经验丰富的调查员(Renaud)。所有这些共同补充了UPR-RP在MBRS计划的支持下已经持续了32年的生物医学研究工作，特别是加强了目前的SCORE计划，该计划包括14个常规项目和3个试点项目(化学10个，生物5个，数学2个)。这些新项目的共同目标是在以下领域开展竞争性研究：拉丁美洲幽门螺杆菌的生物种群多样性(Domanguez)、谷氨酸在药物调节中的作用(Maldonado)、阿片剂戒断对人类巨噬细胞的影响(Renaud)以及来自加勒比海洋无脊椎动物的新型抗癌和抗菌药物(Rodriguez)。 这些调查将由一个正在进行的行政项目以及包括四名实验室技术员和三名博士后助理在内的技术和支助人员进行。这一增强型Score计划将为该机构提供一流的研究和开发机会以及充分支持的研究氛围，从而帮助参与计划的教师提高他们的生物医学研究生产率、科学竞争力和同行认可度。该计划的研究活动还加强了该机构现有的MARC U*STAR计划和MBRS-RISE计划。将通过既定的评估计划，每年对每个新项目的具体目标和方案总体目标的进展情况进行评估。

DESCRIPTION (provided by applicant): This supplemental application requests the addition of four new projects to the SCORE Program currently active at the University of Puerto Rico, Rio Piedras. The projects included are three from the Department of Biology and one from Chemistry. One from Biology (Maldonado) and another from Chemistry (Rodriguez) are revised applications according to the critiques reported in the summary statement for our SCORE application. Another is presented from a recently hired microbiologist (Dominguez) and the other is from an experienced investigator that participated in the previous grant cycle (Renaud). All together complement biomedical research efforts at UPR-RP that have been ongoing for over 32 years under the auspicies of the MBRS program and specifically, strengthen the present SCORE Program which groups 14 regular and 3 pilot projects (10 in Chemistry, 5 in Biology and 2 in Mathematics). Together these new projects aim to conduct competitive research in areas related to: biodemographic diversity of Helicobacter pylori in Latin America (Dominguez), the role of glutamate in drug conditioning (Maldonado), the effect of opiate withdrawal on human macrophages (Renaud), and novel anticancer and antibacterial drugs from Caribbean marine invertebrates (Rodriguez). These investigations are to be sustained by an ongoing administrative project and by technical and support personnel that include four laboratory technicians and three postdoctoral associates. This enhanced SCORE Program will provide this institution first-rate research and development opportunities as well as a fully supportive research atmosphere and will thus help the participating faculty to increase their biomedical research productivity, scientific competitiveness and peer recognition. Research activities in the program also enhance the existing MARC U*STAR Program and the MBRS-RISE Program at this institution. Progress in the specific aims of each new project and in the overall aims of the program will be evaluated yearly through an established Evaluation Plan.