Support for Enhancement Excellence in Research at UPR-RP

描述(由申请人提供)：这份第二份补充申请要求在目前在波多黎各大学里约热内卢分校开展的SCORE计划中增加三个常规项目和一个试点项目。包括三个来自生物系的项目和一个来自化学的项目。其中两个是根据我们的SCORE申请(Soderquist)和第一个补充申请(Domguez)的摘要声明中报告的批评而修订的申请。另一份来自最近聘用的进化生物学家和数量遗传学家(Hrbek)，另一份来自参与上一轮赠款周期的初级研究员(Giray)。所有这些共同补充了UPR-RP在MBRS计划支持下已经进行了33年的生物医学研究工作，特别是加强了目前的SCORE计划，该计划包括14个常规项目和3个试点项目(10个化学项目，5个生物项目和2个数学项目)。这些新项目的共同目标是在以下领域开展竞争性研究：(1)不同人类种群混合产生的幽门螺杆菌和氨基酸幽门螺杆菌类型的替换和菌株间转换，以及对疾病的潜在影响(多明格斯)；(2)在蜜蜂模型中理解肌肉(运动)与成年行为发育的整合(Giray)；(3)开发一个模型系统，用于评估Aplocheiloide鱼类超家族中与生物医学相关的复杂特征，衰老和发育滞育，这些特征随着环境压力而进化(Hrbek)，以及(4)发明和开发合成非外消旋胺和氨基酸的新方法，这些手性构建块在合成药物和复杂天然产品方面具有广泛的潜在应用(Soderquist)。 这些调查将由一个正在进行的行政项目以及包括四名实验室技术员和三名博士后助理在内的技术和支助人员进行。这一增强型Score计划将为该机构提供一流的研究和开发机会以及充分支持的研究氛围，从而帮助参与计划的教师提高他们的生物医学研究生产率、科学竞争力和同行认可度。该计划的研究活动还加强了该机构现有的MARC U*STAR计划和MBRS-RISE计划。将通过既定的评估计划，每年对每个新项目的具体目标和方案总体目标的进展情况进行评估。

DESCRIPTION (provided by applicant): This second supplemental application requests the addition of three regular and one pilot projects to the SCORE Program currently active at the University of Puerto Rico, Rio Piedras. The projects included are three from the Department of Biology and one from Chemistry. Two of these are revised applications according to the critiques reported in summary statements of our SCORE application (Soderquist) and of the first supplemental application (Dominguez). Another is presented from a recently hired evolutionary biologist and quantitative geneticist (Hrbek) and the other is from a junior investigator that participated in the previous grant cycle (Giray). All together complement biomedical research efforts at UPR-RP that have been ongoing for over 33 years under the auspicies of the MBRS program and specifically, strengthen the present SCORE Program which groups 14 regular and 3 pilot projects (10 in Chemistry, 5 in Biology and 2 in Mathematics). Together these new projects aim to conduct competitive research in areas related to (1) replacement and inter-strain conversion of Helicobacteri and amino acids pylori types resulting from the mixing of different human populations, and potential impact on disease, (Dominguez); (2) the understanding of the integration of muscle (motor) with adult behavioural development in a bee model (Giray); (3) the development of a model system for evaluating biomedically relevant complex traits, senescence and developmental diapause, in the fish super family of Aplocheiloide that has evolved these traits in response to environmental pressures (Hrbek), and (4) to the invention and development of new methods for the synthesis of non-racemic amines and amino acids, chiral building blocks which have a wide range of potential applications for the synthesis of pharmaceuticals and complex natural products (Soderquist). These investigations are to be sustained by an ongoing administrative project and by technical and support personnel that include four laboratory technicians and three postdoctoral associates. This enhanced SCORE Program will provide this institution first-rate research and development opportunities as well as a fully supportive research atmosphere and will thus help the participating faculty to increase their biomedical research productivity, scientific competitiveness and peer recognition. Research activities in the program also enhance the existing MARC U*STAR Program and the MBRS-RISE Program at this institution. Progress in the specific aims of each new project and in the overall aims of the program will be evaluated yearly through an established Evaluation Plan.