MRI-enhanced Endoscopy with tracking-imaging probes

带跟踪成像探头的 MRI 增强内窥镜检查

• 批准号: 7117378
• 负责人: Erez Nevo
• 金额: $ 49.52万
• 依托单位: ROBIN MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7117378
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical research; cryotherapy; electrical conductance; endoscopy; gastrointestinal imaging /visualization; histology; human subject; image guided surgery /therapy; image processing; magnetic resonance imaging; monitoring device; swine

DESCRIPTION (provided by applicant): The Phase-II project aims to develop tracking and imaging probe (TIP) for MR-enhanced endoscopy. MRI has many advantages over traditional optical and ultrasound endoscopy, such as excellent soft tissue contrast and temperature-sensitive imaging. The use of Robin Medical's proprietary tracking technology with local imaging will enable high-resolution MR imaging during endoscopy and is expected to improve the yield of endoscopic interventions, for example by replacing open surgery with image-guided, minimally-invasive endoscopy. The specific aims of Phase-2 are: To develop the final configuration of the TIP; To integrate the TIP into MR-compatible endoscopes; To conduct animal studies for safety assessment and to evaluate the performance of the system in-vivo; To conduct pilot human studies to demonstrate the clinical efficacy of MR-aided endoscopy. The TIP, an innovative hollow probe that enables tracking and imaging, will be integrated into the tip of MR-compatible endoscope. Matching and tuning circuitry will be developed to interface the TIP to standard MR scanners. The animal studies will include temperature monitoring of the endoscope during MRI, imaging normal wall, imaging wall structure following induction of lesions, and imaging effect of cryotherapy. Limited series of human endoscopy procedures will compare polyp structure by MR-endoscopy to histology sections.

描述（由申请人提供）： II期项目旨在开发MR增强内窥镜检查的跟踪和成像探针（TIP）。 MRI比传统的光学和超声内窥镜检查具有许多优势，例如出色的软组织对比度和对温度敏感的成像。 Robin Medical的专有跟踪技术与局部成像一起使用将在内窥镜检查过程中实现高分辨率MR成像，并有望提高内窥镜干预措施的产量，例如，通过使用图像引导的，微弱的内窥镜检查来代替开放手术。 阶段2的具体目的是：开发尖端的最终配置；将尖端整合到兼容MR兼容的内窥镜中；进行动物研究以进行安全评估并评估系统中系统的性能；进行试验人类研究以证明MR ADED内窥镜检查的临床功效。 尖端，一种创新的空心探针，可以使跟踪和成像进行整合到兼容MR兼容的内窥镜尖端中。将开发匹配和调谐电路，以将尖端与标准MR扫描仪连接。动物研究将包括在MRI期间对内窥镜的温度监测，成像正常壁，诱导病变后的成像壁结构以及冷冻疗法的成像效应。有限的人类内窥镜程序系列将通过MR构镜检查与组织学切片进行比较。