MRI-enhanced Endoscopy with tracking-imaging probes

描述（由申请人提供）：该项目旨在开发用于MR增强内窥镜检查的集成跟踪和成像探头。与传统的光学和超声内镜相比，MRI具有许多优点，如良好的软组织对比度和温度敏感成像。Robin Medical专有的实时跟踪技术与局部成像的结合使用将使内窥镜尖端附近的高分辨率MR成像成为可能，并有望通过用图像引导的微创干预取代开放式手术来提高各种内窥镜干预（例如胃肠道内窥镜检查）的产量。第一阶段的具体目标是：1）设计和制造集成跟踪和成像探头（TIP），并开发使成像线圈与标准MR扫描仪匹配和调谐所需的电路;以及2）评估交互扫描期间TIP成像的性能（从属于跟踪传感器），TIP将作为柔性印刷电路板实现，并将与Robin Medical分包商合作生产。电路设计将基于理论和实验RF电路设计概念。将制造定制校准体模，以便能够直接比较TIP成像获得的图像与表面和体线圈的标准MR成像。

DESCRIPTION (provided by applicant): The project aims to develop an integrated tracking and imaging probe for MR-enhanced endoscopy. MRI has many advantages over the traditional optical and ultrasound endoscopy, such as excellent soft tissue contrast and temperature-sensitive imaging. The use of Robin Medical's proprietary realtime tracking technology with local imaging will enable high-resolution MR imaging near the tip of the endoscope and is expected to improve the yield of various endoscopic interventions, for example gastrointestinal endoscopy, by replacing open surgery with image-guided, minimally-invasive interventions. The specific aims of Phase I are: 1) to design and manufacture an integrated tracking and imaging probe (TIP) and to develop the electrical circuitry needed to match and tune the imaging coils to standard MR scanners; and 2) to evaluate the performance of TIP imaging during interactive scanning (slaved to the tracking sensor), The TIP will be realized as a flexible printed circuit board and will be produced in collaboration with an established Robin Medical subcontractor. The electrical circuitry design will be based on theoretical and experimental RF circuit design concepts. A custom calibration phantom will be manufactured to enable direct comparison of images obtained with TIP imaging to standard MR imaging with surface and body coils.