Novel Devices for Management of Toxic Alcohol Exposure

用于管理有毒酒精暴露的新型设备

• 批准号: 7072223
• 负责人: HANS G KLOEPFER
• 金额: $ 37.26万
• 依托单位: MICRONIX, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7072223
• 关键词: alcohol oxidoreductases; aldehyde /ketone oxidoreductase; biomedical equipment development; blood chemistry; blood toxicology; clinical trials; colorimetry; consumable /disposable biomedical equipment; ethylene glycols; formates; glycolates; human subject; hydrogen peroxide; longitudinal human study; methanol; method development; miniature biomedical equipment; patient oriented research; portable biomedical equipment; rapid diagnosis

DESCRIPTION (provided by applicant): The applicant organization proposes to develop ultra-miniaturized, minimally invasive test wand methods for quantification in whole blood specimens of methanol, formate, ethylene glycol, and glycolate, the four critical analytes in the laboratory evaluation of toxic alcohol exposure. The methods dose and transport a blood sample in the nanoliter range to an integrated polymeric detection site. The detection site embodies dried chemical reagents capable of reacting with analyte, as well as a polymeric composition capable of absorbing a defined volume of blood plasma while preventing cellular component of blood from penetrating the composition. Cells are wholly removed from the detection site by proprietary chemical and physical mechanisms, thereby obviating the need for a separate cell-filtering material and unmasking the detection site for instrumented or visual analysis. Instrumented analysis is performed by means of a hand-held transmittance monitoring meter. Test procedure and performance time are streamlined by consolidating all testing steps into one single disposable device. Primary target markets are emergency room and other critical care environments.

描述（由申请人提供）：申请人组织提议开发超微小化的，微创的测试棒方法，用于在甲醇，甲酸盐，甲酸酯，乙烯甘油和甘氨酸的全血样本中进行定量，这是实验室毒性酒精暴露的四个关键分析物。该方法在纳米素范围内剂量并将血液样品剂量转移到集成的聚合检测位点。检测位点体现了能够与分析物反应的干化学试剂，以及能够吸收定义的血浆量的聚合物组合物，同时防止血液的细胞成分穿透组合物。通过专有的化学和物理机制将细胞完全从检测位置清除，从而避免了需要单独的细胞过滤材料并揭示检测位点进行仪器或视觉分析。仪器分析是通过手持式透射监控仪进行的。通过将所有测试步骤合并到一个一次性设备中，可以简化测试过程和性能时间。主要目标市场是急诊室和其他重症监护环境。