Novel Solid State Diabetes Monitoring System

新型固态糖尿病监测系统

• 批准号: 6643134
• 负责人: HANS G KLOEPFER
• 金额: $ 38.26万
• 依托单位: MICRONIX, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643134
• 关键词: beta hydroxybutyrate; bioengineering /biomedical engineering; biomedical equipment development; blood chemistry; blood glucose; cholesterol; clinical research; diabetes mellitus; diabetic angiopathy; glycation; hemoglobin As; human tissue; insulin; miniature biomedical equipment; patient monitoring device; polymers; triglycerides

DESCRIPTION (provided by applicant): The applicant organization proposes to develop an ultra-miniaturized, minimally invasive diabetes monitoring system for estimating concentrations of diabetes-related parameters (analytes) in whole blood. The system is comprised of analyte specific test tabs and a hand-held meter. The test tabs dose and transport a blood sample in the nanoliter range (approximately 300nL) to an integrated polymeric detection site. The detection site embodies dried chemical reagents capable of reacting with analyte, as well as a polymeric composition capable of absorbing a defined volume of blood plasma while preventing cellular component of blood from penetrating the composition. Cells are wholly removed from the detection site by proprietary chemical and physical mechanisms, thereby obviating the need for a separate cell filtering material and unmasking the detection site for visual or instrumented analysis. Test procedure is streamlined and performance time drastically reduced by consolidating all testing steps into one single disposable device. Primary target markets are point-of-care and self-testing environments.

描述（由申请人提供）： 申请人组织提议开发一种超微小的，微创的糖尿病监测系统，以估计全血的糖尿病相关参数（分析）的浓度。该系统由分析物特定的测试选项卡和手持仪表组成。测试标签剂量并在纳米素范围内（约300NL）的血液样品转运到集成的聚合检测位点。检测位点体现了能够与分析物反应的干化学试剂，以及能够吸收定义的血浆量的聚合物组合物，同时防止血液的细胞成分穿透组合物。通过专有的化学和物理机制将细胞完全从检测位置中移除，从而消除了需要单独的细胞过滤材料的需求，并删除了检测位点进行视觉或仪器分析。通过将所有测试步骤合并到一个一次性设备中，可以简化测试过程，并大大降低性能时间。主要目标市场是护理点和自我测试环境。