Growth Factor Coated Sutures for Improved Tendons Repair

描述（由申请人提供）：肌腱损伤是相当常见的，这些损伤的频率预计将随着人口老龄化而上升，但继续保持活跃。需要长时间的固定和康复，因为肌腱愈合是一个相对缓慢的过程。通过提高愈合率和增加修复组织的强度来缩短这一时间的创新将对患者和社会具有重大价值。早期活动被认为可以促进更好的功能恢复，加速愈合，并改善肌腱修复组织的质量。然而，这种早期的运动和活动不能以增加两个肌腱末端的间隙或甚至明显的再断裂为代价。已经尝试使用超声波、机械刺激和生长因子来增加愈合率，以提供足够的机械强度，从而允许患者开始将负荷施加在愈合肌腱上的活动，同时仍然保护初始缝合修复的完整性。该I期SBIR提案的目标是验证IFBM方法，以将生物活性分子（如生长因子）结合到不可吸收聚酯缝线（Bispond，Ethicon，Inc.），其通常用于许多类型的肌腱修复。我们提出了一种新的方法来创建结合生物活性剂（生长因子，细胞等）的靶向特异性模块肽。到合成的生物相容性表面（基质聚合物、金属等）。这些指定和接枝生物聚合物被称为“界面生物材料”（IFBM）。双功能IFBM具有以下独特优点：a）提供必需的表面结合特异性，B）包含用于广泛应用的稳健化学，以及c）提供在单个支架或表面上指定广泛范围的相关或独立生物活性的能力。软骨衍生的形态发生蛋白（CCRs）-1、-2和-3（也称为BMP-14、-13和-12）最近被证明参与肌腱发育和愈合。我们认为，通过IFBM技术将生长因子（如Cyclic家族的生长因子）与缝线结合，可以通过提高愈合率和改善修复组织的质量，显著改善肌腱手术修复后的临床结局。

DESCRIPTION (provided by applicant): Tendon injuries are quite common and the frequency of these injuries is expected to rise as the population ages, yet continues to remain active. Long periods of immobilization and rehabilitation are required because tendon healing is a relatively slow process. Innovations that can shorten this time period by improving healing rates and increasing the strength of repair tissue will be of great value for patients and society. Earlier activity is believed to promote better return of function, accelerated healing, and improved quality of tendon repair tissue. However, this early motion and activity cannot be at the cost of increasing gapping of the two tendon ends or even frank re-rupture. Attempts have been made with ultrasound, mechanical stimulation, and growth factors to increase healing rates to provide enough mechanical strength to allow patients to start activity that will put load on the healing tendons, while still protecting the integrity of the initial suture repair. The goal of this Phase I SBIR proposal is to validate an IFBM approach to bind bioactive molecules such as growth factors to non-absorbable polyester suture (Ethibond, Ethicon, Inc.), which is commonly used in many types of tendon repair. We present a novel approach to create target-specific modular peptides that bind bioactive agents (growth factors, cells, etc.) to synthetic biocompatible surfaces (matrix polymer, metal, etc.). These specifying and grafting biopolymers are termed "interfacial biomaterials" (IFBMs). A bi-functional IFBM has the unique advantages of a) providing requisite surface binding specificity, b) comprising robust chemistry for broad-based applications and c) offering capacity to specify a wide range of associated or independent biological activities onto a single scaffold or surface. Cartilage derived morphogenetic proteins (CDMP) -1, -2 and -3 (also known as BMP -14, -13, and -12) have recently been shown to be involved in tendon development and healing. We believe that binding growth factors such as those of the CDMP family to suture with IFBM technology could significantly improve the clinical outcomes after surgical repair of tendons by increasing healing rates and by improving the quality of the repair tissue.