KURU EXPERIMENTS TRIGGERED THE EMERGENCE OF PATHOGENIC SIVMAC

KURU 实验引发了致病性 SIVMAC 的出现

• 批准号: 7349103
• 负责人: CRISTIAN APETREI
• 金额: $ 6.54万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349103
• 关键词: KURU; EXPERIMENTS; TRIGGERED; EMERGENCE; PATHOGENIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have identified three lines of evidence which show that the pathogenic SIVmac strains used in AIDS animal model studies most likely originated as a result of kuru experiments conducted in the US in the 1970s. Specifically we have found: (1) A strong link in the time and location of experiments involving intracranial passaging of sooty mangabey brain tissue to macaques and SIVmac emergence. (2) A significant association of clusters of SIVmac strains within kuru study groups. And, (3) Confirmation of seroconversion in the specific macaques used in the kuru experiments. Therefore, it is plausible that highly invasive experimental manipulations, and not casual contact, inadvertently gave rise to a highly pathogenic SIV isolate, used from the 1980¿s to the present time.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。我们已经确定了三组证据，表明艾滋病动物模型研究中使用的致病性 SIVmac 菌株很可能源自 20 世纪 70 年代美国进行的库鲁实验。具体来说，我们发现：（1）涉及黑白眉猴脑组织颅内传代给猕猴和 SIVmac 出现的实验的时间和地点之间存在密切联系。 (2) 库鲁研究组内 SIVmac 菌株簇的显着关联。并且，(3) 确认库鲁实验中使用的特定猕猴的血清转化。因此，从 20 世纪 80 年代至今一直使用的高侵入性实验操作（而非偶然接触）可能无意中产生了高致病性 SIV 分离株。