Gastrokine 2: a novel stomach-specific tumour suppressor gene

Gastrokine 2：一种新型胃特异性抑癌基因

• 批准号: nhmrc : 546430
• 负责人: Dr Trevelyan Menheniott
• 金额: $ 22.85万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gastrokine-2-novel-suppressor-gene/82436
• 关键词: Gastrokine; novel; stomach; specific; tumour

We will evaluate how a natural protein called gastrokine 2 acts to prevent cancer from developing in the stomach. We will show how gastrokine 2 interacts with another stomach protein TFF1, to block the effects of the inflammatory and cancer causing bacterium Helicobacter pylori, and the way that this bacterium circumvents this by turning off the production of gastrokine 2. Finally a drug which inhibits stomach tumour growth by turning on gastrokine 2 will be tested.

我们将评估一种叫做胃因子2的天然蛋白质是如何防止胃癌发生的。我们将展示胃因子2如何与另一种胃蛋白TFF1相互作用，以阻止引起炎症和癌症的幽门螺杆菌的影响，以及这种细菌如何通过关闭胃因子2的产生来规避这一影响。最后，将测试一种通过激活胃因子2来抑制胃肿瘤生长的药物。