Novel epigenetic and molecular determinants of gastric cancer initation and progression

胃癌发生和进展的新表观遗传学和分子决定因素

• 批准号: nhmrc : 1026674
• 负责人: Dr Trevelyan Menheniott
• 金额: $ 28.87万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-epigenetic-molecular-initation-progression/110512
• 关键词: Novel; epigenetic; molecular; determinants; gastric

Over one million deaths from stomach cancer occur annually. This often fatal disease can be caused by infection with the bacterium H. pylori. I am a molecular biologist seeking to understand how inflammation caused by H. pylori drives a genetic signature which can be used to predict stomach cancer risk. I will also study how a new family of stomach proteins can prevent tumour growth. My research aims to lead new initiatives for early detection and treatment of stomach cancer.

每年有100多万人死于胃癌。这种通常是致命的疾病可能是由感染幽门螺杆菌引起的。我是一名分子生物学家，试图了解幽门螺杆菌引起的炎症是如何驱动一种可用于预测胃癌风险的基因签名的。我还将研究一种新的胃蛋白家族如何防止肿瘤生长。我的研究旨在引领早期发现和治疗胃癌的新举措。