Ensemble Neural Monitoring and Saccadic Control

描述(由申请者提供)：教官研究计划的总体目标是阐明调节眼球跳动的神经机制并监测眼球跳动的后果。整体神经活动将从执行停止信号任务的猕猴的额叶眼场(FEF)和辅助眼场(SEF)记录下来。这项任务允许识别控制眼跳的神经信号和监控性能的神经信号。这个项目的具体目标是研究FEF中的运动相关信号是如何协调来控制眼跳启动的，以及SEF中的性能监测信号如何影响FEF来影响行为调节。这些目标将通过在FEF和SEF内和跨FEF同时记录多个神经元来实现。这一建议的力量在于，在一个易于处理的行为范式中建立了关于执行控制的假设，具有强大的理论基础和良好的眼运动系统解剖学和生理学基础。培训的目标是发展行为控制认知理论方面的专业知识，以及从大脑皮层区域同时记录的神经元收集和分析数据的方法。

DESCRIPTION (provided by applicant): The overall goal of the preceptor's research program is to elucidate the neural mechanisms that regulate the initiation and monitor the consequences of saccadic eye movements. Ensemble neural activity will be recorded from the frontal eye field (FEF) and supplementary eye field (SEF) of macaque monkeys performing a stop-signal task. This task permits identification of neural signals that control saccades and neural signals that monitor performance. The specific goals of this project are to investigate how movement-related signals in FEF are coordinated to control saccade initiation and how performance monitoring signals in SEF influence FEF to effect behavioral adjustments. These goals will be achieved by recording multiple neurons simultaneously within and across FEF and SEF. The strength of this proposal is the grounding of hypotheses about executive control in a tractable behavioral paradigm with a strong theoretical foundation and the well-established anatomy and physiology of the ocular motor system. The training goal is to develop expertise in cognitive theories of behavioral control and in methods of collecting and analyzing data from simultaneously-recorded neurons across cortical areas.