Ensemble Neural Monitoring and Saccadic Control

整体神经监测和扫视控制

• 批准号: 7279792
• 负责人: MELANIE W LESLIE
• 金额: $ 1.89万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-01-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7279792
• 关键词: Anatomy; Area; Behavior; Behavior Control; Behavioral; Behavioral Paradigm; Cognitive; Data Analyses; Feedback; Foundations; Goals; Individual; Laboratories; Macaca; Methods; Monitor; Monkeys; Movement; Neurons; Performance; Physiology; Play; Preparation; Psychological reinforcement; Reaction Time; Research; Role; Saccades; Signal Transduction; System; Task Performances; Training; Variant; Visual Fields; Work; base; executive function; frontal eye fields; gaze; neuromechanism; oculomotor; programs; relating to nervous system; theories

DESCRIPTION (provided by applicant): The overall goal of the preceptor's research program is to elucidate the neural mechanisms that regulate the initiation and monitor the consequences of saccadic eye movements. Ensemble neural activity will be recorded from the frontal eye field (FEF) and supplementary eye field (SEF) of macaque monkeys performing a stop-signal task. This task permits identification of neural signals that control saccades and neural signals that monitor performance. The specific goals of this project are to investigate how movement-related signals in FEF are coordinated to control saccade initiation and how performance monitoring signals in SEF influence FEF to effect behavioral adjustments. These goals will be achieved by recording multiple neurons simultaneously within and across FEF and SEF. The strength of this proposal is the grounding of hypotheses about executive control in a tractable behavioral paradigm with a strong theoretical foundation and the well-established anatomy and physiology of the ocular motor system. The training goal is to develop expertise in cognitive theories of behavioral control and in methods of collecting and analyzing data from simultaneously-recorded neurons across cortical areas.

描述（由申请人提供）：导师研究计划的总体目标是阐明调节眼球运动启动和监测眼球运动后果的神经机制。将从执行停止信号任务的猕猴的额眼场（FEF）和辅助眼场（SEF）记录整体神经活动。该任务允许识别控制眼跳的神经信号和监控表现的神经信号。该项目的具体目标是研究 FEF 中的运动相关信号如何协调以控制眼跳启动，以及 SEF 中的性能监控信号如何影响 FEF 以实现行为调整。这些目标将通过在 FEF 和 SEF 内部以及之间同时记录多个神经元来实现。该提案的优势在于，关于执行控制的假设以易于处理的行为范式为基础，具有坚实的理论基础和完善的眼运动系统解剖学和生理学。培训目标是培养行为控制认知理论以及收集和分析皮层区域同时记录的神经元数据的方法方面的专业知识。