Ensemble Neural Monitoring and Saccadic Control

整体神经监测和扫视控制

• 批准号: 7155767
• 负责人: MELANIE W LESLIE
• 金额: $ 4.88万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155767
• 关键词: behavior; eye; neurons; performance; saccades

DESCRIPTION (provided by applicant): The overall goal of the preceptor's research program is to elucidate the neural mechanisms that regulate the initiation and monitor the consequences of saccadic eye movements. Ensemble neural activity will be recorded from the frontal eye field (FEF) and supplementary eye field (SEF) of macaque monkeys performing a stop-signal task. This task permits identification of neural signals that control saccades and neural signals that monitor performance. The specific goals of this project are to investigate how movement-related signals in FEF are coordinated to control saccade initiation and how performance monitoring signals in SEF influence FEF to effect behavioral adjustments. These goals will be achieved by recording multiple neurons simultaneously within and across FEF and SEF. The strength of this proposal is the grounding of hypotheses about executive control in a tractable behavioral paradigm with a strong theoretical foundation and the well-established anatomy and physiology of the ocular motor system. The training goal is to develop expertise in cognitive theories of behavioral control and in methods of collecting and analyzing data from simultaneously-recorded neurons across cortical areas.

描述（由申请人提供）：导师研究计划的总体目标是阐明调节扫视眼球运动的启动和监测其后果的神经机制。将从执行停止信号任务的猕猴的额眼场（FEF）和补充眼场（SEF）记录被包围神经活动。这项任务允许识别控制扫视的神经信号和监控表现的神经信号。本研究的具体目标是探讨FEF中的运动相关信号如何协调以控制眼跳启动，以及SEF中的表现监测信号如何影响FEF以实现行为调整。这些目标将通过同时记录FEF和SEF内和跨FEF和SEF的多个神经元来实现。这一建议的力量是执行控制的假设在一个易于处理的行为范式与强大的理论基础和完善的解剖学和生理学的眼运动系统的基础。培训目标是发展行为控制的认知理论以及收集和分析来自皮层区域错误记录的神经元的数据的方法。