Nuclear envelope membrane proteins and nuclear structure

核膜膜蛋白和核结构

• 批准号: 7235342
• 负责人: MEGAN C KING
• 金额: $ 1.59万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7235342
• 关键词: ATP phosphohydrolase; Binding; Cell physiology; Chromatin Structure; Complex; Depth; Disease; Disruption; Dystonia Musculorum Deformans; Eukaryotic Cell; Gatekeeping; Gene Expression Regulation; Genome; Genomics; Goals; Lamins; Lead; Maintenance; Membrane; Membrane Proteins; Monitor; Nature; Nuclear; Nuclear Envelope; Nuclear Pore Complex; Nuclear Structure; Process; Proteins; Role; Signal Transduction; Site; Structure; Tertiary Protein Structure; Testing; TorsinA; Transmembrane Domain; Yeasts; base; early onset; emerin; lamin B receptor; polypeptide; protein function

DESCRIPTION (provided by applicant): The nuclear envelope (NE) has long been appreciated as a gatekeeper to the genome of eukaryotic cells, restricting genomic access only to those molecules capable of traversing the NE via nuclear pore complexes (NPCs). It is increasingly evident, however, that the NE performs active and essential roles in genomic organization beyond providing simple compartmentalization of DMA. NE-associated complexes are important for maintenance of chromatin structure, gene regulation, and DMA replication. Disruption of the NE structure can lead to disregulation of these processes. This proposal focuses on the role of NE membrane proteins in maintaining the structural integrity provided by the NE, with a particular focus on the role of the transmembrane (TM) and lumenal domains of NE membrane proteins.

描述（由申请人提供）：核被膜（NE）长期以来被认为是真核细胞基因组的看门人，其将基因组访问仅限制于能够经由核孔复合物（NPC）穿过NE的那些分子。然而，越来越明显的是，NE在基因组组织中发挥着积极和重要的作用，而不仅仅是提供简单的DMA区室化。NE相关复合物对于维持染色质结构、基因调控和DNA复制是重要的。NE结构的破坏可导致这些过程的失调。该建议侧重于NE膜蛋白在维持NE提供的结构完整性中的作用，特别关注NE膜蛋白的跨膜（TM）和内腔结构域的作用。

项目成果

A network of nuclear envelope membrane proteins linking centromeres to microtubules.

• DOI: 10.1016/j.cell.2008.06.022
• 发表时间: 2008-08-08
• 期刊: CELL
• 影响因子: 64.5
• 作者: King, Megan C.;Drivas, Theodore G.;Blobel, Guenter
• 通讯作者: Blobel, Guenter