Animal Resource Improvement: YNPRC

描述（由申请人提供）：尽管在过去十年中取得了重大的科学进步，改善了治疗方法并有望研制出疫苗，但艾滋病仍然是世界范围内的一个主要医疗问题，每年有数百万人感染和死亡。如果我们要成功地遏制并消除这一全球祸害，就必须继续在艾滋病研究方面取得进展。非人类灵长类动物模型的可用性是进行开发更好的治疗方法和疫苗所需的基础研究和临床前测试的关键要求。NIH/NCRR支持的Yerkes NPRC多年来在艾滋病动物模型研究中发挥了重要作用，为这项工作分配了大量资源。艾滋病相关的研究项目在YNPRC继续增加，主要由美国国立卫生研究院资助。近年来，随着非人灵长类动物模型的研究在许多领域变得越来越重要，该中心的研究项目和研究支持活动的范围都在加速增长。因此，对支持对国家卫生需求至关重要的研究所需的基础设施的需求在耶基斯和全国都有所增加。该提案要求资金将现有的传统灵长类动物住房设施改造为BSL-2+灵长类动物住房设施，适合饲养分配给艾滋病相关研究方案的猴子。该设施的设计将遵循1999年5月CDC-NIH微生物和生物医学实验室生物安全手册第4版中的建议。拟议的改造将为192只动物提供BSL-2+住房，比目前的容量增加66%。所要求的改进将为我们提供急需的专门用于艾滋病研究的额外住房，这将扩大我们艾滋病相关研究的范围和速度。

DESCRIPTION (provided by applicant): Despite significant scientific advances in the past decade leading to improved treatments and the prospect of a vaccine, AIDS continues to be a major medical problem world-wide, with new infections and deaths in the millions annually. Progress in AIDS research must continue if we are to be successful in containing, then eliminating, this global scourge. The availability of non-human primate models is a critical requirement to conduct the basic research and pre-clinical testing required to develop better treatments and vaccines. The NIH/NCRR supported Yerkes NPRC has played a significant role in AIDS animal model studies for some years - allocating substantial resources to this effort. AIDS related research projects continue to increase at the YNPRC funded largely by the NIH. In recent years, the Center has experienced accelerated growth in the scope of its research programs and research-support activities, as work with nonhuman primate models has become increasingly important in a number of realms. Consequently, the demand for infrastructure needed to support research vital to national health needs has increased both at Yerkes and nationally. This proposal requests funds to renovate an existing conventional primate housing facility into a BSL-2+ Primate Housing Facility suitable for holding monkeys assigned to AIDS-related research protocols. The design of the facility will follow the recommendations in the CDC-NIH Biosafety in Microbiological and Biomedical Laboratories Manual, 4th edition, May 1999. The proposed renovation will provide BSL-2+ housing for up 192 animals, an increase of 66% over current capacity. The requested improvements will provide us with critically needed additional housing dedicated for AIDS studies, which will augment both the scope and pace of our AIDS-related research.