SENSITIVE MEMORY TESTS FOR DIFFERENTIATING MCI SUBGROUPS

用于区分 MCI 子组的灵敏内存测试

• 批准号: 8357430
• 负责人: Stuart Zola
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357430
• 关键词: Alzheimer' s Disease; Award; Behavioral; Clinical; Eye; Funding; Goals; Grant; Impaired cognition; International; Memory; National Center for Research Resources; Nervous system structure; Paired Comparison; Patients; Performance; Populations at Risk; Primates; Principal Investigator; Recruitment Activity; Research; Research Infrastructure; Research Project Grants; Research Subjects; Resources; Risk; Source; Subgroup; Technology; Testing; Therapeutic Intervention; Time; United States National Institutes of Health; Visual; Work; abstracting; base; clinical Diagnosis; cost; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This research project is part of an Alzheimer's Disease Research Center (ADRC) grant awarded in 2005. The major goal of this work is to determine whether sensitive behavioral tasks, together with eye-tracking technology, will reveal a profile of performance in MCI patients that is useful in predicting the onset of Alzheimer's disease. Research subjects were recruited from the ADRC Clinical Core and were tested annually. We have successfully administered the preferential looking task together with eye-tracking in these subjects over several years and are now reviewing performance of these subjects in Year 1 together with their current clinical diagnosis. Our findings, which form the basis of an abstract submission to the International Conference on Alzheimer's Disease (ICAD) 2011, show that those subjects that performed poorly on the visual paired comparison task in the first year of testing are very likely to convert to AD within 4 years. This work is important since it allows us to identify the subset of MCI patients that are most at risk for oncoming cognitive decline. Once therapeutic interventions become available, this would be a key at-risk population to be targeted, at a time when the nervous system is less compromised and, accordingly, more likely to benefit.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该研究项目是2005年阿尔茨海默病研究中心（ADRC）拨款的一部分。这项工作的主要目标是确定敏感的行为任务，以及眼动追踪技术，是否会揭示MCI患者的表现，这对预测阿尔茨海默病的发作是有用的。研究受试者从ADRC临床核心招募，每年进行一次测试。几年来，我们已经成功地在这些受试者中实施了优先注视任务和眼动追踪，现在正在审查这些受试者在第1年的表现以及他们目前的临床诊断。我们的研究结果，这形成了一个抽象的基础上提交给国际会议上阿尔茨海默病（ICAD）2011年，表明那些科目表现不佳的视觉配对比较任务，在第一年的测试是很有可能在4年内转换为AD。这项工作很重要，因为它使我们能够确定MCI患者中最有可能出现认知能力下降的子集。一旦治疗性干预措施变得可用，这将是一个关键的高危人群，在神经系统受损较少的时候，因此，更有可能受益。