CONTE CENTER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目有三项研究，利用了在孔特资助的前一个资助期产生的应激和控制非人类灵长类动物的队列。 研究一考察了早期应激对后续认知能力的影响，重点考察了陈述性和非陈述性记忆功能。分别对内侧颞叶损伤、纹状体损伤和额叶损伤敏感的行为任务被用来评估早期生活应激对后续认知能力，特别是记忆功能的影响。 研究2着眼于早期压力对情绪行为发展的影响，重点是恐惧和焦虑，以及大脑葡萄糖代谢的变化。研究3调查了早期应激是否导致可卡因自我管理比对照组猴子更快获得，以及与对照组猴子相比是否有更多的对灭绝的抵抗力。这些研究使用结构和/或功能脑成像来澄清行为变化和大脑变化之间的关系，并通过神经化学评估来澄清由于早期生活压力而导致的行为变化和脑化学之间的关系。研究1和研究2使用了相同的猴子群体。这既是对一种非常有价值的资源的有效利用，也让我们能够比较同一动物在两个不同行为领域的发现，即记忆和情绪。在必要的情况下，一组完全不同的猴子被用于研究3。 猴子目前正在接受测试，其中几只已经安装了遥测植入物(研究2)，以及正在进行的抽血腿部训练。研究3猴子正在进行训练。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has three studies that utilize the cohorts of stressed and control nonhuman primates generated during the previous funding period of the Conte grant. Study 1 examined the effects of early stress on subsequent cognitive abilities, with an emphasis on declarative and nondeclarative memory functions. Behavioral tasks sensitive to medial temporal damage, to striatal damage, and to frontal lobe damage, respectively are being used to assess the impact of early life stress on subsequent cognitive abilities, especially memory function. Study 2 looked at the effects of early stress on the development of emotional behavior, with an emphasis on fear and anxiety, and changes in cerebral glucose metabolism. Study 3 examined whether early stress resulted in acquiring cocaine self-administration more rapidly than control monkeys, and whether there was more resistance to extinction compared to control monkeys. The studies used structural and/or functional brain imaging to clarify the relationship between behavioral changes and changes in brain, and looked at neurochemical assessments to clarify the relation between behavioral changes and brain chemistry due to early life stress. Study 1 and Study 2 used the same groups of monkeys. This is both an efficient use of a very valuable resource, and it allows us to compare findings in two different domains of behavior, i.e., memory and emotion, in the same animals. By necessity, an entirely separate group of monkeys were used for Study 3. Monkeys are currently being tested and several have been fitted with telemetry implants (Study 2) as well as ongoing leg training for blood draws. Study 3 monkeys are in ongoing training.