Non-genetic paternal effects on offspring reproduction and health: mechanisms and evolutionary consequences in a bird model

非遗传父系对后代繁殖和健康的影响：鸟类模型中的机制和进化后果

• 批准号: 2863964
• 金额: --
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2863964
• 关键词: Non; genetic; paternal; effects; offspring

Evidence is accumulating that a father's condition can be transferred non-genetically to the next generation and affect offspring development, performance and health. To date, the mechanisms underlying such paternal condition transfer effects remain poorly understood and their evolutionary consequences are largely unexplored.In this project you will use a bird model system (Japanese quail, Coturnix japonica), in which paternal condition-transfer effects on offspring reproductive performance have previously been demonstrated, to identify the origin, function and evolutionary consequences of non-genetic paternal effects using a highly multidisciplinary and integrative approach. Using in vivo experiments, combined with state-of-the-art - omics and physiological techniques, you will test how favourable or harsh early life conditions experienced by males affect their sperm and seminal fluid composition, and how different components of the male's ejaculate mediate cross-generational effects on the daughters' reproductive performance and health.Experimental in vivo and molecular work will be complemented by evolutionary modelling to quantify the role of paternal condition-transfer effects in altering the response to selection, as well as the potential of experimental interventions to modify evolutionary trajectories of reproductive traits under selection through paternal effects. The project will provide fundamental novel insights into the mechanisms underlying paternal condition-transfer effects across generations and the potential of early life interventions to alter evolutionary trajectories, both directly relevant to the management of animal health and performance as well as our understanding of the reproductive lives of birds.During the project you will obtain interdisciplinary training in a variety of state-of-the-art approaches and techniques that are highly sought-after by employers in and outside of academia, including experimental in vivo skills, molecular techniques, bioinformatics, and mathematical modelling. You will be based in a thriving, friendly and inclusive department and benefit from the complementary expertise of a highly multidisciplinary supervisory team.Relevant papers:Pick et al (2019) doi: 10.1002/evl3.125Immler (2018) doi: 10.1038/s41437-018-0111-0Gawehns et al (2022) doi: 10.1111/1755-0998.1359

越来越多的证据表明，父亲的病情可以通过非遗传方式遗传给下一代，并影响后代的发育、表现和健康。迄今为止，这种父本条件转移效应背后的机制仍然知之甚少，其进化后果在很大程度上尚未得到探索。在本项目中，您将使用鸟类模型系统（日本鹌鹑、Coturnix japonica），其中先前已证明父本条件转移对后代繁殖性能的影响，以使用高度 多学科和综合方法。使用体内实验，结合最先进的组学和生理技术，您将测试男性经历的有利或严酷的早期生活条件如何影响其精子和精液成分，以及男性射精的不同成分如何介导对女儿的生殖性能和健康的跨代影响。体内实验和分子工作将通过进化模型来补充，以量化 父本条件转移效应在改变选择反应中的作用，以及实验干预通过父本效应改变选择下生殖性状进化轨迹的潜力。该项目将为跨代父系条件转移效应的机制以及早期生命干预改变进化轨迹的潜力提供基本的新颖见解，这两者都与动物健康和性能的管理以及我​​们对鸟类生殖生活的理解直接相关。在该项目期间，您将获得各种最先进的方法和技术的跨学科培训，这些方法和技术受到国内外雇主的高度追捧。 学术界的知识，包括体内实验技能、分子技术、生物信息学和数学建模。您将在一个蓬勃发展、友好和包容的部门工作，并受益于高度多学科监督团队的互补专业知识。相关论文：Pick et al (2019) doi: 10.1002/evl3.125Immler (2018) doi: 10.1038/s41437-018-0111-0Gawehns et al (2022) doi: 10.1111/1755-0998.1359