APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS

描述（由申请人提供）：本提案的目的是支持西南国家灵长类动物研究中心（SNPRC）的持续发展。SNPRC位于其主办机构西南生物医学研究基金会的校园内。SNPRC保存着6000多种非人灵长类动物，包括狒狒、恒河猴、食蟹猴、黑猩猩、狨猴、绢毛猴、长尾猴、蜘蛛猴和长尾猴。我们维持着大量狒狒、恒河猴、食蟹猴和狨猴的繁殖种群。我们的动物资源包括世界上最大的圈养狒狒种群，世界上最大的非人类灵长类物种的纯种种群，以及SPF印度裔恒河猴不断增长的种群。在目前的拨款期间，SNPRC为来自27个州的267名研究人员提供了资源。SNPRC分为五类组成部分：行政管理、培训和推广、灵长类群体、资源和资源相关研究组成部分。这些组成部分分为三个组：比较医学、病毒学和免疫学以及遗传学组。持续的资源组成部分包括临床和解剖病理学；兽医技术服务；生物材料收集和分发；血液、组织和DNA存储库；黑猩猩肝炎监测；逆转录病毒诊断;流式细胞术;分子遗传学服务。建议用于发展的额外资源包括行为服务；幼儿园;灵长类基因组数据库；阵列技术;内皮细胞

Description (provided by applicant):The objective of this proposal is to support the continuing development of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Southwest Foundation for Biomedical Research, its host institution. The SNPRC maintains over 6,000 nonhuman primates including baboons, rhesus macaques, cynomolgus macaques, chimpanzees, marmosets, tamarins, vervet monkeys, spider monkeys, and pigtail macaques. We maintain large breeding populations of baboons, rhesus macaques, cynomolgus macaques and marmosets. Our animal resources include the largest captive population of baboons anywhere in the world, the largest pedigreed population of any nonhuman primate species in the world, and a growing population of SPF Indian-origin rhesus macaques. During the current grant period, the SNPRC provided resources to 267 investigators from 27 states. The SNPRC is divided into five types of components: Administrative, Training and Outreach, Primate Colonies, Resource, and Resource-related Research components. These components are organized within three groups: Comparative Medicine, Virology and Immunology, and Genetics Group. Ongoing resource components include clinical and anatomic pathology; veterinary technical services; biomaterials collection and distribution; a blood, tissue and DNA repository; chimpanzee hepatitis surveillance; retrovirus diagnostics; flow cytometry; and molecular genetics services. Additional resources proposed for development include behavioral services; the nursery; a primate genomics database; array technologies; and endothelial cell technologies. Components also are proposed to develop and enhance nonhuman primate models for research on hepatitis, tuberculosis, Chagas' Disease, nematode infection, diabetes and cardiovascular disease.