APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many of the human disorders studied in baboon models are based, at least in part, on a genetic etiology. Transgenesis has been an extremely valuable tool for whole animal, in vivo studies of gene function in the mouse, but it is often not possible to accurately mimic the relevant complex primate physiology in this or other non-primate species. Thus, the availability of transgenic technology for experimental research with baboons would create a powerful new genetic, developmental and physiological model system for biomedical research. The long-term goal of this project is to develop technology for producing transgenic baboons. The immediate goals are to demonstrate the feasibility and to optimize the efficiency of producing transgenic baboon embryos, and to improve the probability of yielding transgenic offspring.