APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在狒狒模型中研究的许多人类疾病至少部分是基于遗传病因学。转基因对于整个动物在小鼠体内的基因功能研究来说是一个非常有价值的工具，但在这个或其他非灵长类物种中，往往不可能准确地模拟相关的复杂灵长类动物的生理。因此，利用转基因技术进行实验研究将为生物医学研究创造一个强大的新的遗传、发育和生理模型系统。该项目的长期目标是开发生产转基因狒狒的技术。目前的目标是证明生产转基因狒狒胚胎的可行性和优化效率，并提高产生转基因后代的可能性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many of the human disorders studied in baboon models are based, at least in part, on a genetic etiology. Transgenesis has been an extremely valuable tool for whole animal, in vivo studies of gene function in the mouse, but it is often not possible to accurately mimic the relevant complex primate physiology in this or other non-primate species. Thus, the availability of transgenic technology for experimental research with baboons would create a powerful new genetic, developmental and physiological model system for biomedical research. The long-term goal of this project is to develop technology for producing transgenic baboons. The immediate goals are to demonstrate the feasibility and to optimize the efficiency of producing transgenic baboon embryos, and to improve the probability of yielding transgenic offspring.