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中文摘要
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描述(由申请者提供):本申请响应RFA-OD-09-005,“恢复法案限制竞争:支持新教师招聘以通过生物医学研究核心中心增强研究资源(第30页)。我们建议聘请一位对神经干细胞生物学或间充质干细胞生物学特别感兴趣的干细胞研究领域的新助理教授,作为圣安东尼奥细胞和分子灵长类动物研究所(SAICMP)的一名研究员,该研究所是一个生物医学核心中心,并在UTSA的生物系担任终身教职助理教授。根据本RFA的一般指导方针,UTSA是符合条件的机构,并且是本RFA作为西班牙裔服务机构的专门目标机构。SAICMP的使命是促进利用灵长类和其他相关模型系统的互动研究,以研究干细胞及其分化的衍生物的基本生物学,特别是优化和测试方案,用于潜在的治疗应用于人类患者。过去对人类患者过早应用基因治疗或更新的基于干细胞的治疗应用的经验表明,在通过相关动物模型系统的临床前测试确保这些方案的有效性和安全性之前,将这些方案适应于人类是危险的。我们为助理教授(终身教职)级别的新招聘提供了一个极好的机会,拥有非常强大的机构支持和在学术界和生物医学研究领域发展非常成功的职业生涯的潜力。我们承诺在以下方面提供广泛的机构支持:持续的国家支持工资、个人实验室空间、终身教职职位、获得SAICMP所有成员、生物系教员和/或UTSA科学学院教员的所有资源,以及有机会加入一个独特的干细胞生物学家团队,从事基于干细胞的治疗方法研究的独特但高度相关的非人类灵长类动物模型。因此,这项申请是对RFA的回应,它寻求资金,以允许创造一个在来年无法提供的职位(工作)。
英文摘要
DESCRIPTION (provided by applicant): This application responds to RFA-OD-09-005, "Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers (P30). We propose to hire a new Assistant Professor in the area of Stem Cell Research, with a specific interest in either Neurological Stem Cell Biology or Mesenchymal Stem Cell Biology as an Investigator in the San Antonio Institute for Cellular and Molecular Primatology (SAICMP), a Biomedical Core Center, and the Department of Biology at UTSA, as a tenure-track Assistant Professor. UTSA is an Eligible Institution under the general guidelines of this RFA, and is a specifically targeted institution for this RFA as an Hispanic-Serving Institution. The mission of the SAICMP is to promote interactive research utilizing primate and other relevant model systems to investigate the basic biology of stem cells and their differentiated derivatives, and especially to optimize and test protocols for potential therapeutic application in human patients. Past experiences involving the premature application of either gene therapy or more recent stem-cell-based therapeutic applications to human patients have demonstrated the dangers of adapting these protocols to humans prior to ensuring their efficacy and safety by pre-clinical testing in relevant animal model systems. We define an excellent opportunity for a new hire at the Assistant Professor (tenure-track) level, with very strong institutional support and potential for development of a highly successful career in academia and biomedical research. We commit extensive institutional support in terms of ongoing state-supported salary, individual laboratory space, a tenure-track position, access to all resources afforded to all members of the SAICMP, the Department of Biology faculty, and/or the College of Sciences faculty at UTSA, and the opportunity to join a unique team of stem cell biologists working with a unique, but highly relevant nonhuman primate model for studies of stem-cell-based therapeutic approaches. Thus, this application is responsive to the RFA by seeking funds that will allow the creation of a position (job) that will not otherwise be made available during the coming year.
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Germline-mediated Transgenerational Epigenetic Inheritance of Paternal Epimutations Induced by a High Fat Diet
Germline-mediated Transgenerational Epigenetic Inheritance of Paternal Epimutations Induced by a High Fat Diet
Germline-mediated Transgenerational Epigenetic Inheritance of Paternal Epimutations Induced by a High Fat Diet
Epimutations in Offspring Produced by Assisted Reproductive Technologies (ART)
  • 批准号:
    8757199
  • 项目类别:
  • 资助金额:
    $62.76万
  • 财政年份:
    2014
  • 负责人:
    John R MCCARREY
  • 依托单位:
海外基金