Gene Discovery in Large Multiplex Families with Autism Spectrum Disorders

患有自闭症谱系障碍的大型多重家庭的基因发现

• 批准号: nhmrc : 1044175
• 负责人: A/Pr Paul Lockhart
• 金额: $ 58.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gene-discovery-large-spectrum-disorders/111636
• 关键词: Gene; Discovery; Large; Multiplex; Families

Autism spectrum disorders (ASD) are neurodevelopmental disorders of childhood with lifelong impact. ASD are characterised by deficits in communication, language development and restricted behaviours or interests. ASD have a genetic basis likely due to multiple genes but the cause is not known in more than 75% of cases. This project will discover genes associated with ASD by studying large families in which several children have ASD and identify new targets for treatment.

自闭症谱系障碍(ASD)是一种影响终生的儿童神经发育障碍。自闭症的特点是缺乏沟通、语言发展和受限的行为或兴趣。ASD有一个遗传基础，可能是由于多个基因，但在超过75%的病例中，病因尚不清楚。该项目将通过研究几个儿童患有自闭症的大家庭来发现与自闭症相关的基因，并确定新的治疗靶点。