Analysis of the role of PACRG in spermatogenesis

PACRG在精子发生中的作用分析

• 批准号: nhmrc : 436977
• 负责人: A/Pr Paul Lockhart
• 金额: $ 25.12万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-role-pacrg-spermatogenesis/95415
• 关键词: Analysis; role; PACRG; spermatogenesis

Approximately 1 in 25 men in the western world are infertile, and while environmental and genetic factors are recognized to contribute to disease, there is currently a poor understanding of the basic mechanisms regulating male fertility. Our long term goal is to identify and study key molecules involved in sperm production. Understanding the role of these molecules will provide insight into the causes of male infertility. Ultimately, these studies will assist to develop new treatments for male reproductive disorders. Conversely, there is a huge need for additional male based contraceptives. Increased understanding of male fertility and identification of proteins exclusively involved in sperm production provides the opportunity to develop new contraceptive treatments.

在西方世界，大约每25名男性中就有一人不育，虽然环境和遗传因素被认为是导致疾病的原因，但目前对调节男性生育的基本机制了解很少。我们的长期目标是识别和研究与精子产生有关的关键分子。了解这些分子的作用将有助于深入了解男性不育的原因。最终，这些研究将有助于开发治疗男性生殖障碍的新疗法。相反，对更多以男性为基础的避孕药具的需求很大。增加对男性生育能力的了解和识别专门参与精子产生的蛋白质，为开发新的避孕方法提供了机会。