Determining The Role Of Parkin and PACRG In Protein turnover

确定 Parkin 和 PACRG 在蛋白质周转中的作用

• 批准号: nhmrc : 1046206
• 负责人: A/Pr Paul Lockhart
• 金额: $ 37.06万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-role-parkin-protein-turnover/111825
• 关键词: Determining; Role; Parkin; PACRG; Protein

Alterations in the parkin gene are associated with neurodegenerative disorders such as Parkinson's disease (PD). The aim of this proposal is to characterise the function of parkin and the role it plays in disease development. We will determine the role of parkin in the brain and how loss of this function causes specific nerve cells to die. These studies will provide the means to develop novel therapeutic approaches to alleviate or prevent these disorders.

parkin基因的改变与神经退行性疾病如帕金森病（PD）有关。该提案的目的是阐明parkin的功能及其在疾病发展中的作用。我们将确定帕金在大脑中的作用，以及这种功能的丧失如何导致特定的神经细胞死亡。这些研究将为开发新的治疗方法以减轻或预防这些疾病提供手段。