COBRE:UVM PROJ 2:MOLECULAR & GENETIC ANALYSIS OF LEARNED FEAR REDUCTION IN MICE

描述(由申请人提供)：本申请的目标是 建立神经科学生物医学卓越研究中心(COBRE) 在佛蒙特州大学(UVM)。这项建议的具体目标是： 具体目标1：建立研究和智力基础设施，以 支持密歇根州立大学神经科学卓越研究中心。的目标 这一目标包括：1)建立一个辅导计划，以支持青少年 神经科学学院；2)建立成像/生理学核心以支持 初级教员的研究项目；3)建立一个 细胞/分子核心支持低年级学生的研究项目 教职员工；4)建立全大学神经科学研讨会系列并 神经科学年会；5)建立沟通机制 基础科学家和临床医生之间的合作，促进 翻译研究和6)建立全校范围的机制 神经科学研究生教育。 具体目标2：支持青少年核心群体的研究开发 未来将成为神经科学卓越中心领导者的教职员工。 将得到支持的教职员工和他们的项目标题是：1)Rona Delay博士， 生物系：嗅神经细胞的氯离子动态平衡； 威廉福尔斯，心理学系：分子和基因分析 在老鼠身上学习减少恐惧；3)安东尼·莫里耶利博士， 药理：钾通道的激酶和细胞骨架调节； 马修·兰德，解剖和神经生物学系：蛋白质分解调节 Notch信号在神经发生中的作用和5)George Wellman博士， 药理学：蛛网膜下腔出血中脑血管痉挛的机制。 密歇根大学在神经科学的三个领域建立了研究人员： 分子/发育、细胞/系统和临床/行为 神经科学。这项申请的裁决将提供一种机制，以 显著扩展这些神经科学现有领域的研究实力 重视基础与临床神经科学的结合，促进 大学范围内的研究合作。在研究方面的卓越水平 如果没有外部支持，培训是不可能实现的。 初级和高级调查人员的工作效率都将得到激发， 将创建长期指导框架。UVM是中国的一家小型机构 一个资源有限的农村州；一个奖项将大大扩大我们的 研究基础设施，并显著提高教师竞争力。

DESCRIPTION (provided by applicant): The goal of this application is to establish a Center of Biomedical Research Excellence (COBRE) in Neuroscience at the University of Vermont (UVM). The specific aims of this proposal are: Specific Aim 1: Establish the research and intellectual infrastructure to support a University-wide Center for Neuroscience Excellence at UVM. Goals of this aim include: 1) to establish a mentoring program to support junior neuroscience faculty; 2) to establish an imaging/physiology core to support the research projects of the junior faculty; 3) to establish a cellular/molecular core to support the research projects of the junior faculty; 4) to establish a University-wide Neuroscience Seminar Series and Annual Neuroscience Retreat; 5) to establish a mechanism of communication between basic scientists and clinicians that facilitates development of translational research and 6) to establish a University-wide mechanism for Neuroscience Graduate Education. Specific Aim 2: Support the research development of a core group of junior faculty who will be future leaders in the Center for Neuroscience Excellence. Faculty to be supported and their project titles are: 1) Dr. Rona Delay, Department of Biology: Chloride homeostasis in olfactory neurons; 2) Dr. William Falls, Department of Psychology:Molecular and genetic analysis of learned fear reduction in mice; 3) Dr. Anthony Morielli, Department of Pharmacology: Kinase and cytoskeletal regulation of potassium channels; 4) Dr. Matthew Rand, Department of Anatomy and Neurobiology: Proteolytic modulation of Notch signaling in neurogenesis and 5) Dr. George Wellman, Department of Pharmacology: Mechanisms of cerebral vasospasm in subarachnoid hemorrhage. UVM has established investigators in three areas of neuroscience: molecular/developmental, cellular/systems and clinical/behavioral neuroscience. Award of this application would provide a mechanism to significantly expand research strength in these existing areas of neuroscience emphasis, to integrate basic with clinical neuroscience, and to promote research collaborations university-wide. A level of excellence in research and training will be fostered that is not possible without external support. Productivity of both junior and senior investigators will be stimulated, and a long term mentoring framework will be created. UVM is a small institution in a rural state with limited resources; an award would substantially expand our research infrastructure and significantly increase faculty competitiveness.