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Olfactory neuromodulation of visual circuits and behavior

视觉回路和行为的嗅觉神经调节

基本信息

批准号：
10177297
负责人：
Mark Arthur Frye
金额：
$ 38.05万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10177297
关键词：
Affect Aging Animals Ballistics Basic Science Behavior Behavioral Biogenic Amines Biological Models Brain Cells Chemicals Cognitive Complex Couples Degenerative Disorder Detection Discrimination Disease Drosophila genus Food Functional disorder Ganglia Genetic Models Genetic Techniques Goals Home Human Image Individual Knowledge Lead Link Locomotion Logic Maps Mission Modality Modeling Molecular Motion Motor Movement National Institute of Neurological Disorders and Stroke Nervous system structure Neurons Norepinephrine Octopamine Odors Olfactory Pathways Optic Lobe Optics Output Pathology Pathway interactions Pattern Perception Population Process Property Reflex action Research Resolution Saccades Sensory Signal Pathway Signal Transduction Smell Perception Smooth Pursuit Source Spatial Distribution Stimulus Stroke Synapses System Testing Transcript Traumatic injury United States Vision Visual Writing behavioral response brain health chemical function cognitive function detector disability falls fly functional disability improved in vivo in vivo calcium imaging multimodality multisensory neurogenetics neuronal circuitry neuroregulation nonhuman primate octopamine receptor optogenetics public health relevance receptive field relating to nervous system response sensor sensory input two-photon virtual reality virtual reality system visual control visual feedback visual processing

项目摘要

Project summary A significant percentage of people in the US suffer from disabilities resulting from traumatic injury, stroke, or degenerative disease which result in enigmatic deficits in cognitive function. Therefore, an understanding of the fundamental properties of neuronal circuits for complex brain function, and how these circuits are modulated by biogenic amines, will sharpen our understanding of the normal brain, thereby highlighting pathology and facilitating treatments. A major function of the brain is to integrate information across sensory modalities to enable sharp and robust perception. The cell-circuit mechanism for how different sensory modalities interact is not well understood. This project will capitalize on the significant experimental advantages of the fruit fly Drosophila to explore the molecular logic and neural connections that produce an elementary form of multisensory integration perception. The fly displays robust multisensory perception, integrating olfactory signals with visual processing to enhance perceptual abilities. Furthermore, sensory circuits have been shown to be under robust neuromodulatory control by biogenic amines. Similar processes have been localized to sub- cortical and cortical pathways in humans and non-human primates. The fly has a numerically compact nervous system, with which highly advanced genetic techniques can be used to identify, manipulate, and record activity from individual neurons and neurosecretory cells, as well as their upstream and downstream synaptic partners and molecular components. The PI hypothesizes that the fly brain couples olfactory sensory detection to visual processing through neuromodulatory cells that carry the chemical equivalent of norepinephrine. The PI will perform two-photon Ca2+ imaging to ‘read’ activity from live flies in response to stimuli the PI has discovered elicit robust multi-modal integration behavior within a virtual reality system. The PI will use optogenetics imaging to ‘write’ signals into these circuit pathways to assess input-output functions from an intact behaving fly.

项目总结