Siemens Acuson Sequoia Ultrasound Machine

描述(由申请人提供)： 这项提议的目标是为威斯康星大学医学院的NIH资助的研究人员提供一种最先进的超声成像系统。心血管内科和威斯康星大学人口健康科学部有着成功和富有成效的合作历史，在心脏病学和心血管疾病流行病学方面取得了高质量的研究。购买超声成像系统将促进并显著提高本拨款申请中所述的几个正在进行的NIH支持的研究项目的科学质量。西门子Acuson Sequoia C512是一款最先进的多功能心脏和血管超声成像仪器。我们正在寻求共享超声系统的所有资助研究都将利用它作为工具，更好地了解睡眠呼吸紊乱、高血压、糖尿病、充血性心力衰竭和心肌梗死的生理后果。这三个“主要”用户是共享仪器的理想群体，因为他们在睡眠呼吸障碍和心血管疾病方面有共同的研究兴趣，他们需要高质量的超声波来评估心血管结构和功能，他们与首席调查员有着密切的合作关系，以及他们作为R01资助的活跃研究人员的地位。所有六名研究人员都使用了几种基于超声的研究技术，包括评估颈动脉内膜-中层厚度、臂动脉反应性、脑血流量、冠脉血流量以及左心室收缩和舒张期功能。由于诊断性超声波没有已知的生物学效应，可以纵向进行系列研究，以评估疾病过程的不同阶段及其对干预措施的反应。由于华盛顿大学医学院目前不存在进行这些研究所需的研究设备，因此必须从已经超额订购的临床实验室借入或购买时间，这是一种昂贵且不方便的安排。必要的空间、行政支持、监督和技术专长已经到位，以确保所需的设备在威斯康星州大学立即可操作并具有很高的生产力。如果将超声系统作为共享资源提供给威斯康星大学医学院，将有更大的机会加强合作，提高研究效率，并节省成本。

DESCRIPTION (provided by applicant): The goal of this proposal is to make a state-of-the-art ultrasound imaging system available for NIH-funded researchers at the University of Wisconsin (UW) Medical School. The Section of Cardiovascular Medicine and the UW Department of Population Health Sciences have a strong history of successful and productive collaborations that have resulted in high-quality research in cardiology and the epidemiology of cardiovascular disease. Acquisition of an ultrasound imaging system will facilitate and significantly enhance the scientific quality of several ongoing NIH-supported research projects described in this grant application. The Siemens Acuson Sequoia C512 is a state-of-the-art, multipurpose instrument for cardiac and vascular ultrasound imaging. All of the funded research studies for which we are seeking a shared ultrasound system will use it as a tool to better understand the physiological consequences of sleep-disordered breathing, hypertension, diabetes mellitus, congestive heart failure, and myocardial infarction. The three "major" users are an ideal group to share instrumentation given their common research interests in sleep-disordered breathing and cardiovascular disease, their need for high-quality ultrasound to assess cardiovascular structure and function, their strong collaborative relationships with the Principal Investigator, and their status as active, R01-funded investigators. All six investigators use several ultrasound-based research techniques including the evaluation of carotid intima-media thickness, brachial artery reactivity, cerebral blood flow, coronary blood flow, and left ventricular systolic and diastolic function. Because diagnostic ultrasound has no known biological effects, serial studies can be performed longitudinally to evaluate various stages of disease processes and their responses to interventions. Since the research equipment needed to perform these studies currently does not exist in the UW Medical School, it must be borrowed or time purchased from an already oversubscribed clinical laboratory, an expensive and inconvenient arrangement. The necessary space, administrative support, supervision, and technical expertise already are in place to assure that the requested equipment will be operable immediately and highly productive at UW. There is significant opportunity for greater collaboration, research productivity, and cost savings if an ultrasound system is made available at the UW Medical School as a shared resource.