MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AW

建议：(改编自申请者的摘要)：斯坦博士将制定一项 通过临床高级培训从事以患者为中心的研究 研究设计、生物统计学、脂蛋白生物化学和高级 超声波研究技术。他还将接受道德方面的培训 人类受试者研究的开展。他的长期目标是成为一名 国内和国际公认的临床研究员，开发 用于诊断和管理患者的治疗策略和测试 有动脉粥样硬化性血管疾病或有患动脉粥样硬化性血管疾病的风险。作为他研究的一部分 职业发展计划，斯坦博士将完成威斯康星大学临床分校 调查员准备路径(CIPP)。作为这一计划的一部分，他将 获得研究设计、生物统计学和流行病学方面的高级培训 通过UWMS生物统计学和医学专业的课程和指导学习 信息学统计数据分析中心。他将接受培训，在 脂蛋白生物化学和脂类实验室技术课程和 在威斯康星州大学医学院医院脂类和脂蛋白实验室指导研究。他会的 接受高级颈动脉超声研究技术培训 维克森林大学(WFU)医学超声中心。其他内容 关于伦理学和人类受试者研究规则的指导， 领导力、教学和科学写作是职业生涯的组成部分 发展规划。研究计划将决定新陈代谢是否 与使用人类免疫缺陷病毒(HIV)蛋白酶相关的变化 抑制物是致动脉粥样硬化的，取决于它们对内皮细胞的影响。 功能(通过血流介导的肱动脉血管扩张来衡量)和 早期动脉粥样硬化(通过颈动脉内膜-中层增厚来衡量)。 通过血管超声获得的这些参数的异常 技术，预测不良心血管事件。斯坦博士还将评估 HIV蛋白水解酶抑制剂对致动脉粥样硬化脂蛋白的影响 他在职业发展计划中获得了高级脂类实验室技能。 最后，斯坦博士将确定这些药物是否有损于餐后健康 通过评估脂质和蛋白质清除含甘油三酯脂蛋白 脂蛋白对口服脂肪负荷的反应。

PROPOSAL: (Adapted from the applicant's abstract): Dr. Stein will develop a career in patient-oriented research by obtaining advanced training in clinical research design, biostatistics, lipoprotein biochemistry, and advanced ultrasound research techniques. He also will receive training in the ethical conduct of human subjects research. His long-term goal is to become a nationally and internationally recognized clinical investigator who develops therapeutic strategies and tests for the diagnosis and management of patients with or at risk for atherosclerotic vascular disease. As part of his research career development plan, Dr. Stein will complete the UWMS Clinical Investigator Preparatory Pathway (CIPP). As part of this program, he will obtain advanced training in research design, biostatistics, and epidemiology through courses and directed study in the UWMS Biostatistics and Medical Informatics Statistical Data Analysis Center. He will obtain training in lipoprotein biochemistry and lipid laboratory techniques through courses and directed study in the UWMS Hospital Lipid and Lipoprotein Laboratory. He will obtain training in advanced carotid ultrasound research techniques in the Center for Medical Ultrasound at Wake Forest University (WFU). Additional instruction regarding ethics and human subjects research regulations, leadership, teaching, and scientific writing are components of the career development plan. The research plan will determine whether the metabolic changes associated with use of human immunodeficiency virus (HIV) protease inhibitors are atherogenic, as determined by their effects on endothelial function (measured by flow-mediated vasodilation of the brachial artery) and early atherosclerosis (measured by carotid intimal-medial thickening). Abnormalities of these parameters, which are obtained by vascular ultrasound techniques, predict adverse cardiovascular events. Dr. Stein also will assess the effects of HIV protease inhibitors on atherogenic lipoproteins using the advanced lipid laboratory skills he obtains in the career development plan. Finally, Dr. Stein will determine if these medications impair postprandial clearance of triglyceride-containing lipoproteins by assessing lipid and lipoprotein responses to an oral fat load.