MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AW

提案：（改编自申请人摘要）：Stein博士将开发一种 通过接受临床高级培训，从事以患者为中心的研究职业 研究设计、生物统计学、脂蛋白生物化学和高级 超声波研究技术 他还将接受道德培训， 开展人类受试者研究。 他的长期目标是成为 国内和国际公认的临床研究者， 用于诊断和管理患者的治疗策略和测试 患有动脉粥样硬化性血管疾病或有患动脉粥样硬化性血管疾病的风险。 作为研究的一部分 职业发展计划，斯坦博士将完成UWMS临床 研究者预备途径（CIPP）。 作为该计划的一部分，他将 获得研究设计、生物统计学和流行病学方面的高级培训 通过课程和UWMS生物统计学和医学方向的研究 信息学统计数据分析中心。 他将接受培训， 脂蛋白生物化学和脂质实验室技术通过课程， UWMS医院脂质和脂蛋白实验室的指导研究。 他将 接受高级颈动脉超声研究技术的培训， 维克森林大学（WFU）医学超声中心。 额外 关于伦理和人类受试者研究法规的指导， 领导力、教学和科学写作是职业生涯的组成部分 发展规划 这项研究计划将确定是否代谢 与使用人类免疫缺陷病毒（HIV）蛋白酶相关的变化 抑制剂是致动脉粥样硬化的，如通过其对内皮细胞的作用所确定的。 功能（通过肱动脉的血流介导的血管舒张测量）和 早期动脉粥样硬化（通过颈动脉内膜-中膜增厚测量）。 通过血管超声获得的这些参数的摘要 技术，预测不良心血管事件。 斯坦博士还将评估 HIV蛋白酶抑制剂对致动脉粥样硬化脂蛋白的影响， 他在职业发展计划中获得的高级脂质实验室技能。 最后，斯坦博士将确定这些药物是否会损害餐后 通过评估脂质和 脂蛋白对口服脂肪负荷的反应。

PROPOSAL: (Adapted from the applicant's abstract): Dr. Stein will develop a career in patient-oriented research by obtaining advanced training in clinical research design, biostatistics, lipoprotein biochemistry, and advanced ultrasound research techniques. He also will receive training in the ethical conduct of human subjects research. His long-term goal is to become a nationally and internationally recognized clinical investigator who develops therapeutic strategies and tests for the diagnosis and management of patients with or at risk for atherosclerotic vascular disease. As part of his research career development plan, Dr. Stein will complete the UWMS Clinical Investigator Preparatory Pathway (CIPP). As part of this program, he will obtain advanced training in research design, biostatistics, and epidemiology through courses and directed study in the UWMS Biostatistics and Medical Informatics Statistical Data Analysis Center. He will obtain training in lipoprotein biochemistry and lipid laboratory techniques through courses and directed study in the UWMS Hospital Lipid and Lipoprotein Laboratory. He will obtain training in advanced carotid ultrasound research techniques in the Center for Medical Ultrasound at Wake Forest University (WFU). Additional instruction regarding ethics and human subjects research regulations, leadership, teaching, and scientific writing are components of the career development plan. The research plan will determine whether the metabolic changes associated with use of human immunodeficiency virus (HIV) protease inhibitors are atherogenic, as determined by their effects on endothelial function (measured by flow-mediated vasodilation of the brachial artery) and early atherosclerosis (measured by carotid intimal-medial thickening). Abnormalities of these parameters, which are obtained by vascular ultrasound techniques, predict adverse cardiovascular events. Dr. Stein also will assess the effects of HIV protease inhibitors on atherogenic lipoproteins using the advanced lipid laboratory skills he obtains in the career development plan. Finally, Dr. Stein will determine if these medications impair postprandial clearance of triglyceride-containing lipoproteins by assessing lipid and lipoprotein responses to an oral fat load.