EVALUATION OF HYPERCAPNIA-INDUCED CHANGES IN CFV BY TTDE IN HEALTHY SUBJECTS

通过 TTDE 评估健康受试者中高碳酸血症引起的 CFV 变化

• 批准号: 7375546
• 负责人: JAMES H STEIN
• 金额: $ 0.71万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375546
• 关键词: EVALUATION; HYPERCAPNIA; INDUCED; CHANGES; CFV

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is completed. Background: The effect of hypercapnia on the coronary arteries in humans is currently unknown. This pilot study assessed the feasibility of using transthoracic Doppler echocardiography (TTDE) in healthy adults to detect changes in coronary artery blood flow velocity (CFV) with varying levels of inspired CO2. Methods: Healthy adults underwent TTDE of the distal left anterior descending coronary artery (LAD) while breathing room air, oxygen supplemented to 40% of inspired air, and CO2 adjusted to +5, +7.5, and +10 mm Hg above their baseline partial end-tidal CO2 (PET CO2) levels on a background of 40% FiO2. CFV and other parameters were measured at each experimental state. Mean peak diastolic CFV values were compared at each state using one-way analysis of variance of repeated measures. Results: Among twenty adults (mean [standard deviation] age 33 [6] years, 52% female, 90% white), TTDE images could be acquired at all experimental conditions in 17 subjects. In order of room-air, 40%FiO2, and +5, +7.5, and +10 mm Hg PETCO2 conditions, mean peak (SD) CFV values were 23.1 (9.1) cm/s, 23.0 (9.0) cm/s, 25.5 (9.3) cm/s, 27.9 (11.5) cm/s, and 31.5 (13.0) cm/s. Between-treatment differences were significantly different (p0.001), with p0.05 between progressive levels of hypercapnia, adjusted for multiple comparisons. No significant CFV differences were seen between baseline conditions or between respective baseline and +5 mm Hg PETCO2 states. Conclusions: With progressive levels of hypercapnia, CFV of the LAD in healthy subjects was observed to increase, and these changes could be detected by TTDE.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究完成。背景：高碳酸血症对人类冠状动脉的影响目前尚不清楚。本初步研究评估了在健康成人中使用经胸多普勒超声心动图（TTDE）检测不同吸入二氧化碳水平下冠状动脉血流速度（CFV）变化的可行性。方法：健康成人接受左冠状动脉前降支（LAD）远端TTDE，同时呼吸室内空气，氧气补充到吸入空气的40%，在40% FiO2背景下，将CO2调整到比基线部分尾期CO2 （PET CO2）水平高+5、+7.5和+10 mm Hg。测量了各实验状态下的CFV等参数。使用重复测量的单向方差分析比较各组舒张期CFV平均峰值。结果：20名成人（平均[标准差]年龄33 ~ 30岁，女性52%，白人90%）中，17名受试者在所有实验条件下均可获得TTDE图像。在室内空气、40%FiO2和+5、+7.5和+10 mm Hg PETCO2条件下，CFV的平均峰值（SD）值分别为23.1 (9.1)cm/s、23.0 (9.0)cm/s、25.5 (9.3)cm/s、27.9 (11.5)cm/s和31.5 (13.0)cm/s。治疗间差异有显著性差异（p0.001），累进性高碳酸血症水平之间的差异为p0.05，经多重比较调整。基线条件之间或各自基线和+5毫米汞柱PETCO2状态之间没有明显的CFV差异。结论：随着高碳酸血症水平的进展，健康人LAD的CFV增加，这些变化可以通过TTDE检测到。