Siemens S2000 Cardiovascular Ultrasound System

描述(由申请人提供)：我们的目标是为威斯康星大学动脉粥样硬化成像研究项目(UW AIRP)购买最先进的心血管(CV)超声成像系统，该系统将作为UW医学与公共卫生学院(UW SMPH)NIH资助的研究人员的长期共享资源。具体目标包括：(1)目标1：通过使联邦资助的调查人员更容易获得最先进的超声成像技术，提高威斯康星州州立大学SMPH的CV研究的生产率；(2)目标2： 提高这些研究人员对心血管结构和功能进行临床和动物研究的能力，以及(Iii)目标3：促进开发新的心血管研究，最有效地利用华盛顿大学SMPH的智力、人员和仪器资源。每天约有2200名美国人死于心血管疾病，心血管疾病是美国最主要的死亡原因，这突显了研究心血管疾病机制和治疗的重要性。UW SMPH的心血管超声研究主要在UW AIRP进行，这是一个核心的超声读取、扫描和培训实验室，用于研究动脉粥样硬化负担和心血管风险的研究。2005年4月，UW AIRP主管James Stein博士获得了NCRR S10拨款(RR 021086)，用于购买西门子Acuson Sequoia C512超声系统。自2005年以来，超声波技术有了显著的进步。Sequoia有几个限制，可能会降低UW AIRP及其用户的研究生产率。此外，红杉即将报废，2014年将不再由西门子维修。出于这些考虑，红杉系统需要更换。这项修订后的申请建议购买采用现代软件和换能器技术的最先进的西门子Acuson S2000心血管超声系统。这将促进和提高美国国立卫生研究院资助的几个研究项目的科学质量。将使用新的共享超声系统的研究试图了解心血管疾病风险因素和条件的生理后果和治疗，包括动脉粥样硬化、主动脉瘤、吸烟、睡眠呼吸紊乱、高血压、肺动脉高压、人类免疫缺陷病毒和心力衰竭。主要用户组由5名调查人员组成，其中5名由R01资助，1名由U01资助。次要用户组由4名调查人员组成，拥有3个R01-、1个R21-和1个K23资助的赠款。这些调查人员请求这一工具来帮助他们实现其赠款的具体目标。这些研究所需的超声设备在UW AIRP之外的UW SMPH中并不存在，我们目前的系统正在接近过时。唯一的其他选择是必须从超额认购的临床实验室借来或购买时间的临床设备，这既昂贵又不方便。非常强大的机构支持和技术专长确保所需的设备可以立即投入使用，并在威斯康星州大学实现高生产率。

DESCRIPTION (provided by applicant): Our objective is to purchase a state-of-the-art cardiovascular (CV) ultrasound imaging system for the University of Wisconsin Atherosclerosis Imaging Research Program (UW AIRP), which will function as a long-term, shared resource for NIH-funded investigators at the UW School of Medicine and Public Health (UW SMPH). Specific aims include: (i) Aim 1: To improve the productivity of CV research at the UW SMPH by making state- of-the-art ultrasound imaging more accessible to federally-funded investigators, (ii) Aim 2: To enhance the ability of these investigators to perform clinical and animal studies of CV structure and function, and (iii) Aim 3: To foster the development of new CV research studies that most efficiently use the intellectual, personnel, and instrumentation resources at the UW SMPH. The importance of research into the mechanisms and treatment of CV disease is emphasized by the observations that approximately 2200 Americans die of CV disease each day and that CV disease is the leading cause of death in the United States. CV ultrasound research at the UW SMPH primarily is conducted in the UW AIRP, a core ultrasound reading, scanning, and training laboratory for research studies that investigate atherosclerosis burden and CV risk. In April, 2005, the UW AIRP Director, Dr. James Stein, received a NCRR S10 grant (RR 021086) to purchase a Siemens Acuson Sequoia C512 ultrasound system. Since 2005, ultrasound technology has improved dramatically. The Sequoia has several limitations that risk reducing the research productivity of the UW AIRP and its users. Also, the Sequoia is approaching end-of-life and in 2014 no longer will be serviced by Siemens. Because of these considerations, the Sequoia system needs to be replaced. This revised application proposes purchase of a state-of-the-art Siemens Acuson S2000 cardiovascular ultrasound system with modern software and transducer technology. This will facilitate and enhance the scientific quality of several NIH-supported research projects. The research studies that will use the new shared ultrasound system seek to understand the physiological consequences and treatment of CV disease risk factors and conditions, including atherosclerosis, aortic aneurysm, tobacco use, sleep-disordered breathing, hypertension, pulmonary hypertension, human immunodeficiency virus, and heart failure. The Major users group consists of 5 investigators with 5 R01- and 1 U01-funded grants. The Minor users group consists of 4 investigators with 3 R01-, 1 R21-, and 1 K23-funded grants. These investigators request this instrument to help them achieve their grants' specific aims. The ultrasound equipment needed for these studies does not exist in the UW SMPH outside of the UW AIRP and our current system is approaching obsolescence. The only other option is clinical equipment that must be borrowed or time purchased from an oversubscribed clinical laboratory, which is expensive and inconvenient. Exceptionally strong institutional support and technical expertise assure that the requested equipment will be operable immediately and be highly productive at UW.