Siemens S2000 Cardiovascular Ultrasound System

西门子S2000心血管超声系统

• 批准号: 8436662
• 负责人: JAMES H STEIN
• 金额: $ 16.23万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-20 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8436662
• 关键词: American; Animals; Aortic Aneurysm; Atherosclerosis; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Clinical; Computer software; Development; Equipment; Fostering; Funding; Grant; HIV; Heart failure; Human Resources; Hypertension; Image; Laboratories; Laboratory Research; Minor; National Center for Research Resources; Physiological; Productivity; Public Health; Pulmonary Hypertension; Reading; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Risk Factors; S10 grant; Scanning; Sequoia; Services; Sleep Apnea Syndromes; Structure; System; Technical Expertise; Technology; Time; Tobacco use; Training; Transducers; Ultrasonography; United States; United States National Institutes of Health; Universities; Wisconsin; cardiovascular disorder risk; cardiovascular risk factor; end of life; improved; instrument; instrumentation; medical schools; programs; research study

DESCRIPTION (provided by applicant): Our objective is to purchase a state-of-the-art cardiovascular (CV) ultrasound imaging system for the University of Wisconsin Atherosclerosis Imaging Research Program (UW AIRP), which will function as a long-term, shared resource for NIH-funded investigators at the UW School of Medicine and Public Health (UW SMPH). Specific aims include: (i) Aim 1: To improve the productivity of CV research at the UW SMPH by making state- of-the-art ultrasound imaging more accessible to federally-funded investigators, (ii) Aim 2: To enhance the ability of these investigators to perform clinical and animal studies of CV structure and function, and (iii) Aim 3: To foster the development of new CV research studies that most efficiently use the intellectual, personnel, and instrumentation resources at the UW SMPH. The importance of research into the mechanisms and treatment of CV disease is emphasized by the observations that approximately 2200 Americans die of CV disease each day and that CV disease is the leading cause of death in the United States. CV ultrasound research at the UW SMPH primarily is conducted in the UW AIRP, a core ultrasound reading, scanning, and training laboratory for research studies that investigate atherosclerosis burden and CV risk. In April, 2005, the UW AIRP Director, Dr. James Stein, received a NCRR S10 grant (RR 021086) to purchase a Siemens Acuson Sequoia C512 ultrasound system. Since 2005, ultrasound technology has improved dramatically. The Sequoia has several limitations that risk reducing the research productivity of the UW AIRP and its users. Also, the Sequoia is approaching end-of-life and in 2014 no longer will be serviced by Siemens. Because of these considerations, the Sequoia system needs to be replaced. This revised application proposes purchase of a state-of-the-art Siemens Acuson S2000 cardiovascular ultrasound system with modern software and transducer technology. This will facilitate and enhance the scientific quality of several NIH-supported research projects. The research studies that will use the new shared ultrasound system seek to understand the physiological consequences and treatment of CV disease risk factors and conditions, including atherosclerosis, aortic aneurysm, tobacco use, sleep-disordered breathing, hypertension, pulmonary hypertension, human immunodeficiency virus, and heart failure. The Major users group consists of 5 investigators with 5 R01- and 1 U01-funded grants. The Minor users group consists of 4 investigators with 3 R01-, 1 R21-, and 1 K23-funded grants. These investigators request this instrument to help them achieve their grants' specific aims. The ultrasound equipment needed for these studies does not exist in the UW SMPH outside of the UW AIRP and our current system is approaching obsolescence. The only other option is clinical equipment that must be borrowed or time purchased from an oversubscribed clinical laboratory, which is expensive and inconvenient. Exceptionally strong institutional support and technical expertise assure that the requested equipment will be operable immediately and be highly productive at UW.

描述（由申请人提供）：我们的目标是为威斯康星州大学动脉粥样硬化成像研究项目（UW AIRP）购买最先进的心血管（CV）超声成像系统，该系统将作为UW医学与公共卫生学院（UW SMPH）NIH资助的研究人员的长期共享资源。具体目标包括：㈠目标1：为了通过使联邦资助的研究者更容易获得最先进的超声成像来提高UW SMPH的CV研究的生产率，（ii）目标2： 为了提高这些研究者进行CV结构和功能的临床和动物研究的能力，以及（iii）目标3：促进新CV研究的发展，最有效地利用UW SMPH的智力，人员和仪器资源。每天约有2200名美国人死于CV疾病，CV疾病是美国的主要死因，这一观察结果强调了研究CV疾病机制和治疗的重要性。UW SMPH的CV超声研究主要在UW AIRP进行，UW AIRP是一个核心超声阅读、扫描和培训实验室，用于研究动脉粥样硬化负荷和CV风险的研究。2005年4月，UW AIRP主任James Stein博士获得了NCRR S10赠款（RR 021086），用于购买Siemens Acuson Sequoia C512超声系统。自2005年以来，超声波技术得到了显着改善。Sequoia有几个限制，可能会降低UW AIRP及其用户的研究生产力。此外，Sequoia即将报废，2014年将不再由西门子提供服务。出于这些考虑，红杉系统需要更换。本修订申请建议购买具有现代软件和传感器技术的最先进的Siemens Acuson S2000心血管超声系统。这将促进和提高几个NIH支持的研究项目的科学质量。将使用新的共享超声系统的研究旨在了解心血管疾病风险因素和条件的生理后果和治疗，包括动脉粥样硬化，主动脉瘤，烟草使用，睡眠呼吸障碍，高血压，肺动脉高压，人类免疫缺陷病毒和心力衰竭。主要用户组由5名调查员组成，其中5人获得R01和1人获得U01资助的赠款。未成年人用户组由4名研究人员组成，其中3名R01，1名R21和1名K23资助的赠款。这些调查人员要求这一工具帮助他们实现赠款的具体目标。这些研究所需的超声设备在UW SMPH中不存在于UW AIRP之外，我们目前的系统即将过时。唯一的其他选择是必须从超额认购的临床实验室借用临床设备或购买时间，这是昂贵且不方便的。异常强大的机构支持和技术专业知识确保所需的设备将立即投入使用并在华盛顿大学发挥高效作用。