7-Tesla MR Micro-imaging Console

7-Tesla MR 微型成像控制台

• 批准号: 6877608
• 负责人: Daniel H Turnbull
• 金额: $ 50万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877608
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; disease /disorder model; gene targeting; genetically modified animals; laboratory mouse; magnetic resonance imaging; molecular /cellular imaging; whole body imaging /scanning

DESCRIPTION (provided by applicant): Genetic manipulation in the mouse, using gene targeting and transgene insertions, is now a prevalent method for studying developmental processes and for modeling human diseases. While techniques to alter the genetic makeup of the mouse continue to be refined and used more widely, our ability to rapidly and effectively analyze mutant mouse phenotypes has become the limiting step in many investigations. The Mouse Imaging Facility at NYU School of Medicine employs both ultrasound and magnetic resonance (MR) micro-imaging approaches to analyze anatomical, functional and molecular changes in a wide variety of mouse models, from early embryonic to adult stages of development. There is a long history of support for the Mouse Imaging Facility at NYU School of Medicine, under the joint sponsorship of the Skirball Institute of Biomolecular Medicine and the NYU Cancer Institute. In this application, we request funds to cover the costs of purchasing a new state-of-the-art MR console, bringing our 7-Tesla MR Micro-imaging system up to current standards, and allowing us to continue to support a broad set of NIH-funded projects requiring mouse MRI. This upgrade is well justified, since the console and ancillary equipment are over seven years old, and most of the subsystems are obsolete and difficult or impossible to repair/replace. The research projects currently utilizing MR micro-imaging include analysis of developmental and functional abnormalities in mice with defects in heart and brain development, detection of Multiple Sclerosis lesions in a transgenic mouse model, analysis of tumor progression in mouse models using perfusion MRI and MR spectroscopy, and the development and application of MR contrast reagents targeted to amyloid for plaque detection and monitoring in transgenic mouse models of Alzheimer's Disease. The upgrade of the MR micro-imaging console in the Mouse Imaging Facility will ensure that these innovative and critical applications of mouse MRI will continue to be available to this strong group of NIH-funded investigators.

描述（由申请人提供）： 使用基因靶向和转基因插入，小鼠中的遗传操纵现在是研究发育过程和建模人类疾病的普遍方法。虽然改变小鼠遗传构成的技术继续进行完善并更广泛地使用，但我们快速有效地分析突变小鼠表型的能力已成为许多研究的限制步骤。纽约大学医学院的小鼠成像设施采用超声和磁共振（MR）微成像方法来分析各种小鼠模型的解剖学，功能和分子变化，从早期的胚胎到成人的发育阶段。在Skirball生物分子医学研究所和纽约大学癌症研究所的联合赞助下，纽约大学医学院的老鼠成像设施的支持很长。在本申请中，我们要求资金支付购买新的最先进的MR Console的费用，将我们的7-Tesla MR Micro成像系统提高到当前标准，并允许我们继续支持一套NIH资助的项目，需要鼠标MRI。由于控制台和辅助设备已有7年的历史，因此此升级是有道理的，并且大多数子系统都过时，难以修复/更换。 The research projects currently utilizing MR micro-imaging include analysis of developmental and functional abnormalities in mice with defects in heart and brain development, detection of Multiple Sclerosis lesions in a transgenic mouse model, analysis of tumor progression in mouse models using perfusion MRI and MR spectroscopy, and the development and application of MR contrast reagents targeted to amyloid for plaque detection and monitoring in transgenic mouse models of阿尔茨海默氏病。小鼠成像设施中MR微型成像控制台的升级将确保这一强大的NIH资助的研究人员将继续使用这些创新性和关键的MRI应用程序。