Mouse Imaging

纽约大学癌症研究所(NYUCI)的老鼠成像核心为 在活体小鼠身上使用两种显微成像方法的成员：1)磁共振显微成像 超声生物显微镜(UBM)。这一成像核心在老鼠身上的焦点一直是 其动机是越来越多地使用转基因小鼠作为研究癌症的模型系统。 磁共振和超声成像是临床诊断和治疗中不可缺少的工具 人类癌症的分期。为了充分发挥小鼠癌症模型的潜力，必须开发出 N活体显微成像方法，允许分析疾病进展和对 老鼠体内的治疗剂。鼠标成像核心包括一个30-55 MHz UBM扫描仪和一个7特斯拉 微型核磁共振系统，位于Skirball SPF鼠设施中，可用于非侵入性显微成像， 小鼠血流和血流灌流的功能分析以及UBM引导的操作 早期胚胎到成体发育的阶段。仪器与成像技术的发展 操纵发育过程、检测肿瘤和分析血管生成、肿瘤的方法 形态、进展、退化和转移有可能给癌症研究带来革命性的变化。在……里面 结合转基因和基因打靶方法在小鼠体内进行显微成像 方法为研究分子和遗传机制提供了强大而有效的新工具 潜在的致癌机制。

The Mouse Imaging Core of the New York University Cancer Institute (NYUCI) provides services to members utilizing two micro-imaging methods in the living mouse: 1) magnetic resonance micro-imaging (micro-MRI); and 2) ultrasound biomicroscopy (UBM). The focus of this imaging core on mice has been motivated by the increasing use of genetically engineered mice as model systems for studying cancer. Magnetic resonance and ultrasound imaging are indispensable tools used in the clinical diagnosis and staging of human cancer. To realize the full potential of mouse models of cancer, it is imperative to develop n vivo microscopic imaging approaches, allowing analysis, of disease progression and response to therapeutic agents in mice. The Mouse Imaging Core includes a 30-55 MHz UBM scanner and a 7 Tesla micro-MRI system, both situated in the Skirball SPF Mouse Facility, and available for noninvasive microimaging, functional analysis of blood flow and perfusion, as well as UBM-guided manipulation in mice from early embryonic through adult stages of development. The development of instrumentation and imaging approaches to manipulate developmental processes, to detect tumors and to analyze angiogenesis, tumor morphology, progression, regression and metastases has the potential to revolutionize cancer research. In combination with transgenic and gene targeting approaches in the mouse, in vivo microscopic imaging methods provide powerful and efficient new tools for studying the molecular and genetic mechanisms underlying oncogenesis.