Mouse Imaging

小鼠成像

• 批准号: 7714225
• 负责人: Daniel H Turnbull
• 金额: $ 1.62万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-18 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714225
• 关键词: Abdomen; Adult; Anatomy; Animal Model; Animals; Biological Models; Blood flow; Brain; Cell Proliferation; Cells; Clinical; Contrast Media; Development; Developmental Process; Diagnosis; Disease; Disease Progression; Disease regression; Embryo; Gene Expression; Gene Targeting; Genetic; Genetically Engineered Mouse; Human; Image; Individual; Injection of therapeutic agent; Institutes; Label; Laboratories; Life; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Methods; Microscopic; Molecular Genetics; Monitor; Morphology; Mus; Muscle; Mutant Strains Mice; Neoplasm Metastasis; New York; Numbers; Organ; Pathogenesis; Pathway interactions; Perfusion; Process; Protocols documentation; Purpose; Resolution; Screening procedure; Services; Skin; Staging; System; Techniques; Technology; Therapeutic Agents; Time; Tissues; Transgenic Organisms; Tumor Angiogenesis; Ultrasonographic Biomicroscopy; Ultrasonography; Universities; Virus; anticancer research; blood flow measurement; cancer cell; clinical Diagnosis; genetic manipulation; genetic resource; human disease; in vivo; instrumentation; member; mouse model; neonate; novel strategies; postnatal; response; tool; tumor; tumorigenesis; two-dimensional

The Mouse Imaging Core of the New York University Cancer Institute (NYUCI) provides services to members utilizing two micro-imaging methods in the living mouse: 1) magnetic resonance micro-imaging (micro-MRI); and 2) ultrasound biomicroscopy (UBM). The focus of this imaging core on mice has been motivated by the increasing use of genetically engineered mice as model systems for studying cancer. Magnetic resonance and ultrasound imaging are indispensable tools used in the clinical diagnosis and staging of human cancer. To realize the full potential of mouse models of cancer, it is imperative to develop n vivo microscopic imaging approaches, allowing analysis, of disease progression and response to therapeutic agents in mice. The Mouse Imaging Core includes a 30-55 MHz UBM scanner and a 7 Tesla micro-MRI system, both situated in the Skirball SPF Mouse Facility, and available for noninvasive microimaging, functional analysis of blood flow and perfusion, as well as UBM-guided manipulation in mice from early embryonic through adult stages of development. The development of instrumentation and imaging approaches to manipulate developmental processes, to detect tumors and to analyze angiogenesis, tumor morphology, progression, regression and metastases has the potential to revolutionize cancer research. In combination with transgenic and gene targeting approaches in the mouse, in vivo microscopic imaging methods provide powerful and efficient new tools for studying the molecular and genetic mechanisms underlying oncogenesis.

纽约大学癌症研究所（NYUCI）的小鼠成像中心提供服务， 在活体小鼠中利用两种显微成像方法：1）磁共振显微成像 （micro-MRI）;和2）超声生物显微镜（UBM）。这个成像核心对老鼠的关注已经 这是由于越来越多地使用基因工程小鼠作为研究癌症的模型系统。 磁共振和超声成像是临床诊断中不可或缺的工具， 人类癌症的分期。为了实现小鼠癌症模型的全部潜力，必须开发 体内显微成像方法，允许分析疾病进展和对 小鼠中的治疗剂。鼠标成像核心包括一个30-55 MHz的UBM扫描仪和一个7特斯拉 微型MRI系统，均位于Skirball SPF小鼠设施中，可用于非侵入性显微成像， 血流和灌注的功能分析，以及UBM引导的小鼠操作， 从早期胚胎到成体的发育阶段。仪器和成像的发展 操纵发育过程、检测肿瘤和分析血管生成、肿瘤 形态学、进展、消退和转移具有彻底改变癌症研究的潜力。在 与小鼠中的转基因和基因靶向方法组合，体内显微成像 方法为研究分子和遗传机制提供了强有力的新工具 潜在的肿瘤发生。