COBRE: LSU:PROJ 4:CYCLOOXYGENASES IN NEURONAL SYNAPTIC PLASTICITY

COBRE：LSU：项目 4：神经元突触可塑性中的环加氧酶

• 批准号: 7171014
• 负责人: CHU S CHEN
• 金额: $ 15.28万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171014
• 关键词: neural plasticity; neurosciences

DESCRIPTION (provided by applicant): The LSU-HSC leads a partnership of four Louisiana institutions in a COBRE on neuroscience research. The Program Director and established scientists are mentors to selected, highly promising junior faculty who propose four research projects that have been designed for the common goal of mentoring to build new nationally competitive research. The scientific focus is on a central issue of neurobiology: to understand the cellular and molecular basis of synaptic plasticity and neuronal survival critical to clarify the pathophysiology of neurological disorders such as: stroke, neural trauma and neurodegenerative diseases. This multidisciplinary program involves cellular neurophysiology, molecular biology and behavioral neuroscience. To support the COBRE projects, core resources include facilities for imaging , neurochemistry of lipid messengers and molecular neurobiology. A recruitment plan for years 2 to 5 further benefits the collaborating institutions by actively attracting new research faculty who will work under the guidance of established neuroscientists as mentors. A relatively small administrative core funding is requested. The specific aims to attain these objectives are: 1) to promote faculty development through research projects; 2) to further develop a critical mass of competitive extramurally funded investigators by the recruitment, start up, mentoring and retention of new faculty members; 3) to enhance the infrastructure critical for expanding neuroscience capability in Louisiana by developing three core research modules at LSUHSC; 4) to provide scientific and grantsmanship mentoring and strengthen the support network that promotes interactions; and 5) to implement interim and outcome evaluations so as to keep this COBRE program on track. This partnership rests on existing expertise and in our firm decision to build a scientifically successful neuroscience alliance in Louisiana. The four target faculty and the four to-be-recruited faculty are the critical building blocks to achieve these goals. The core resources are vital to the overall success of this consortium, not only in neuroscience but in all the biomedical sciences. The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana.

描述（由申请人提供）：LSU-HSC 领导了一个由四家公司组成的合作伙伴关系 路易斯安那州 COBRE 神经科学研究机构。该计划 主任和知名科学家是精选的、有前途的科学家的导师 初级教师提出了四个研究项目，这些项目是为 指导建立新的具有全国竞争力的研究的共同目标。 科学重点是神经生物学的一个中心问题：理解 突触可塑性和神经元存活的细胞和分子基础 对于阐明神经系统疾病的病理生理学至关重要，例如： 中风、神经创伤和神经退行性疾病。这个多学科 项目涉及细胞神经生理学、分子生物学和行为学 神经科学。为了支持 COBRE 项目，核心资源包括 成像设备，脂质信使神经化学和分子 神经生物学。第 2 至 5 年的招聘计划进一步有利于 通过积极吸引新的研究人员来合作机构 将在知名神经科学家作为导师的指导下工作。一个 所需的行政核心资金相对较少。具体目标 为实现这些目标： 1）通过以下方式促进教师发展： 研究项目； 2）进一步培养具有竞争力的关键群体 通过招募、启动、指导和培训等方式外部资助研究人员 保留新的教职人员； 3）加强基础设施建设至关重要 通过开发三个核心来扩大路易斯安那州的神经科学能力 LSUHSC 的研究模块； 4）提供科学和资助 指导和加强促进互动的支持网络；和 5) 实施中期和结果评估，以保持 COBRE 计划步入正轨。这种伙伴关系依赖于我们公司现有的专业知识 决定建立一个科学上成功的神经科学联盟 路易斯安那州。四名目标教师和四名拟聘教师分别是 实现这些目标的关键组成部分。核心资源是 对于这个联盟的整体成功至关重要，不仅在神经科学领域，而且 在所有生物医学科学中。指导初级教师的计划 招聘计划将确保源源不断地引进具有国家竞争力的新人才 路易斯安那州的神经科学家。