UKY DENTAL COBRE: ORAL INFECTIONS AND HIV RECRUDESCENCE

英国牙科 COBRE：口腔感染和艾滋病毒复发

• 批准号: 7171338
• 负责人: Chifu Brad Huang
• 金额: $ 20.47万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171338
• 关键词: clinical research; human subject; oral bacteria; periodontitis

DESCRIPTION (provided by applicant): The objectives of the Center for the Biologic Basis of Oral/Systemic Diseases (CBBOSD) are: RESEARCH: To develop a better understanding of the biologic principles that underpin the observed linkages of chronic oral infections and inflammation with systemic disease sequelae; and TRAINING: To use this research focus as a platform to develop promising young investigators in oral health sciences and enhance their competitiveness for external funding, including NIH grant support. We will accomplish these objectives by: Organizing a cadre of established, funded scientists to examine crucial questions related to oral and systemic health linkages, Providing young research faculty with opportunities for interdisciplinary training in oral health sciences and systemic disease, Mentoring young faculty in research projects focused on oral infections, host responses, and systemic disease that will lead to success as independent NIH-funded researchers, Developing and supporting core facilities and resources to optimize the research enterprise of the CBBOSD faculty, Facilitating pilot projects, as well as intra- and inter-university collaborations among CBBOSD faculty, and other researchers at the University of Kentucky, Strategic hiring of new faculty to complement existing strengths to contribute to a critical mass of funded investigators in the biology of oral-systemic diseases. To address this need, we have organized the research activities and leadership of the CBBOSD into 2 broad thematic areas. These thematic areas will incorporate 6 research projects that are integrated with respect to underlying concepts, methodologies, and availability of biological specimens. THEMATIC AREA 1: Oral infections: Translational studies of hostparasite interactions; Project 1: Oral Infections and HIV Recrudescence; Project 2: Oral Infections: Inflammation, Lipid Metabolism, and Atherosclerosis; Project 3: Oral Infections: Genomic Analysis of Host Responses to Polyrnicrobial Infections;. THEMATIC AREA 2: Oral infections: Clinical implications for systemic disease; Project 4: Oral Infections: Impact on Gestational Diabetes; Project 5: Oral Infections: Dietary Regulation of Local and Systemic Inflammatory Responses; Project 6: Oral Infections: Viral/Bacterial Interactions in Chronic Diseases. These research projects are integral to the goals of the CBBOSD because they focus on critical questions of the biology of chronic oral infections and contribution to alterations in systemic health. The overall focus of the CBBOSD is diverse to enable this interdisciplinary research team to: (i) address the myriad of challenges in understanding critical parameters of the interplay between infections and disease in the oral cavity, and (ii) use the available expertise of senior faculty at UK with experience in mentoring young investigators. Thus, junior investigators will be integrated into research projects with established, funded faculty who use state-of-the-art cellular and molecular approaches to explore the biologic basis of this relationship. The breadth of science and varied senior research expertise assures that the CBBOSD will provide opportunities for many junior investigators, who will have the capability to interact within this nurturing environment. The outcomes of this mentored, nurturing structure will enhance the maturation of oral health research at UK, through the College of Dentistry, and synergize in expanding NIH-funded research in the Commonwealth of Kentucky.

描述(由申请人提供)： 口腔/系统疾病生物学基础中心(CBBOSD)的目标是：研究：更好地了解支持所观察到的慢性口腔感染和炎症与系统性疾病后遗症之间联系的生物学原理；以及培训：利用这一研究重点作为平台，培养口腔健康科学领域有前途的年轻研究人员，并提高他们对外部资金的竞争力，包括NIH赠款支持。我们将通过以下方式实现这些目标：组织一批知名的、受资助的科学家研究与口腔和全身健康联系相关的关键问题，为年轻的研究人员提供口腔健康科学和系统性疾病方面的跨学科培训机会，在专注于口腔感染、宿主反应和系统性疾病的研究项目中指导年轻教师，这些研究项目将导致成功地成为NIH资助的独立研究人员，开发和支持核心设施和资源，以优化CBBOSD教员的研究事业，促进试点项目，以及CBBOSD教员和肯塔基大学其他研究人员之间的大学内和大学间的合作，战略性地聘用新的教师，以补充现有的优势，为口腔系统疾病生物学领域的一大批资助研究人员做出贡献。为了满足这一需求，我们将CBBOSD的研究活动和领导分为两大主题领域。这些专题领域将包括6个研究项目，这些项目在基本概念、方法和生物标本的可获得性方面是综合的。专题领域1：口腔感染：寄生虫相互作用的翻译研究；项目1：口腔感染与艾滋病毒复发；项目2：口腔感染：炎症、脂代谢和动脉粥样硬化；项目3：口腔感染：宿主对多种微生物感染反应的基因组分析；专题领域2：口腔感染：全身疾病的临床影响；项目4：口腔感染：对妊娠期糖尿病的影响；项目5：口腔感染：局部和全身炎症反应的饮食调节；项目6：口腔感染：慢性病中的病毒/细菌相互作用。这些研究项目对于CBBOSD的目标是不可或缺的，因为它们专注于慢性口腔感染的生物学和对全身健康变化的贡献等关键问题。CBBOSD的总体重点是多样化的，使这个跨学科的研究团队能够：(I)解决在了解口腔感染和疾病之间相互作用的关键参数方面的各种挑战，以及(Ii)利用英国资深教员在指导年轻研究人员方面的经验。因此，初级研究人员将与现有的、有资金支持的教员一起参与研究项目，他们使用最先进的细胞和分子方法来探索这种关系的生物学基础。科学的广度和不同的高级研究专业知识确保CBBOSD将为许多初级调查人员提供机会，他们将有能力在这个培育环境中互动。这一有指导的培养结构的结果将通过牙科学院促进英国口腔健康研究的成熟，并在肯塔基州联邦扩大NIH资助的研究方面发挥协同作用。