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Identification of anti-cariogenic/low-glycemic activity factors from Lo Han Kuo

罗汉果抗龋齿/低血糖活性因子的鉴定

基本信息

批准号：
7053449
负责人：
Chifu Brad Huang
金额：
$ 10万
依托单位：
ORACEUTICALS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2007-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7053449
关键词：
aging children emotions family health oral health sucrose sweetening agents

项目摘要

DESCRIPTION (provided by applicant): While there exist numerous artificial sweeteners that are commercially available, designed to provide zero- or low-calorie artificial alternatives to sucrose/high fructose corn syrup, there remain concerns regarding potential health concerns in the general population or unique subsets of individuals (e.g. phenylketonurics and diabetics). Moreover, altered sugar alcohol substitute sweeteners, i.e. sorbitol, xylitol, that have been marketed as noncariogenic sweeteners, and more recently as sweeteners for low carbohydrate diets, have been observed to have the potential for gastrointestinal disturbances in some individuals. Thus, there appears to remain a viable market for the identification of novel sweetening agents that can be: (1) used by the general population; (2) demonstrate a anti-cariogenic capacity; (3) have a low glycemic index and negligible negative health effects; (4) has high sweetening index so low amounts can be used; (5) have a chemical structure that maintains its sweetening ability with heating (i.e. baking, cooking), acid conditions (i.e. carbonated drinks), withstand freezing (i.e. ice cream), and can be used as a tabletop sweetening agent; and (6) are natural with many health benefit. This proposal describes studies evaluating a novel zero-calorie high intensive natural sweetener, Lo Han Kuo (LHK) extract, derived from the Chinese Lo Han Kuo fruit (Momordica grosvenori). LHK extract is 300 times sweeter than sucrose and has recently been isolated on an industrial scale; however, little critical research has been conducted to elucidate the sweetening function coupled with biological parameters as related to potential health benefits. A composite of our preliminary studies provides evidence that LHK extract has antibacterial activity against oral microorganisms and has a low-glycemic capability in vitro. In this Phase I proposal, bioactive components will be isolated from LHK extract and their chemical structures determined. These components will be evaluated for their potential anti-caries, anti-periodontitis, and insulin-inductive properties. This proposal is to develop and document methods that will allow the active components of LHK extract to be isolated and characterized. The development of purification and screening methods for functional properties represents the deliverables for Phase I of this STTR. Success of this STTR will define the potential to commercialize a valuable sweetener with therapeutic oral and general health benefits.

描述（由申请人提供）：虽然存在许多市售的人造甜味剂，其被设计为提供蔗糖/高果糖玉米糖浆的零卡路里或低卡路里人造替代品，但仍然存在关于一般人群或个体的独特亚群（例如，苯丙酮酸尿症和糖尿病患者）中的潜在健康问题的担忧。此外，已观察到已作为非致龋甜味剂和最近作为低碳水化合物饮食的甜味剂销售的改变的糖醇替代甜味剂，即山梨糖醇、木糖醇，在某些个体中具有胃肠道紊乱的可能性。因此，似乎仍然存在用于鉴定新甜味剂的可行市场，所述甜味剂可以：（1）由一般人群使用;（2）显示抗龋齿能力;（3）具有低血糖指数和可忽略的负面健康影响;（4）具有高甜味指数，因此可以使用低量;（5）具有在加热时保持其增甜能力的化学结构（即烘焙、烹饪）、酸性条件（即碳酸饮料），耐冷冻（即冰淇淋），并可用作桌面甜味剂;和（6）是天然的，具有许多健康益处。本提案描述了一种新型零热量高强度天然甜味剂罗汉果（LHK）提取物的评价研究，该提取物来自中国罗汉果（罗汉果）。LHK提取物比蔗糖甜300倍，最近已在工业规模上分离;然而，几乎没有进行关键性研究来阐明甜味功能以及与潜在健康益处相关的生物学参数。我们的初步研究的复合材料提供了证据，LHK提取物对口腔微生物具有抗菌活性，并具有体外低血糖能力。在第一阶段计划中，将从LHK提取物中分离出生物活性成分，并确定其化学结构。将评价这些成分的潜在抗龋齿、抗牙周炎和胰岛素诱导特性。该提案旨在开发和记录将允许分离和表征LHK提取物的活性成分的方法。功能特性的纯化和筛选方法的开发代表了本STTR第I阶段的可交付成果。该STTR的成功将确定商业化具有治疗性口服和一般健康益处的有价值甜味剂的潜力。