UKY DENTAL COBRE: ORAL INFECTIONS AND HIV RECRUDESCENCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标1：确定选定的口腔微生物在潜伏感染的T淋巴细胞和巨噬细胞中激活HIV-1的能力。 具体目标2：确定选定的口腔微生物从常驻细胞群中诱导媒介的能力，这些媒介可以激活潜伏感染的T淋巴细胞和巨噬细胞中的HIV-1。 具体目标3：确定细菌和宿主对HIV启动子的刺激以及潜伏感染T细胞和巨噬细胞中HIV重新激活的靶受体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: To determine the capacity of selected oral microorganisms to activate HIV-1 in latently infected T lymphocytes and macrophages. Specific Aim 2: To determine the ability of selected oral microorganisms to elicit mediators from resident cell populations that can activate HIV-1 in latently infected T lymphocytes and macrophages. Specific Aim 3: To determine the target receptors for bacterial and host stimulation of the HIV promoter and HIV reactivation in latently infected T cells and macrophages.