DUKE CENTER FOR GEOSPATIAL MEDICINE

杜克大学地理空间医学中心

• 批准号: 7171446
• 负责人: Marie Lynn Miranda
• 金额: $ 59.45万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171446
• 关键词: biomedical facility; child (0-11); clinical research; congenital nervous system disorder; environmental health; functional /structural genomics; genetics; geographic site; health; health science research support; human data; information systems; interdisciplinary collaboration; method development; quality of life; social psychology; statistics /biometry; training

DESCRIPTION (provided by applicant): Despite an emerging consensus that many diseases are influenced by multiple gene-gene and gene-environment interactions, little is known about how genetic and environmental factors interact to influence outcomes in children. In addition, although psychosocial theory focuses on how socio-economic characteristics influence the health status of children, we have little information about how social factors interact with genetic and environmental factors to affect child well-being. Thus, methods to address the simultaneous and combined influence of social, environmental, and genetic factors are imperative. The mission of Duke's Center for Geospatial Medicine is to develop systematic, spatially-based methods for analyzing the pathways through which the environment, genetic, and psychosocial domains jointly shape child health and well-being. Specific goals of this Center are to: 1) develop an interdisciplinary center that supports research on how genetic, environmental, and social aspects of vulnerability combine to affect children's health and well-being; 2) promote interdisciplinary research interactions among programs in biomedicine, environmental health, statistics, and social sciences; 3) advance new methodologies for incorporating innovative spatial analysis into health research; 4) develop new and creative analytic approaches that address spatial/temporal variation, multiple comparisons, confounding, and effect modification; 5) train young scholars in the resulting methods. We will leverage active partnerships among the Nicholas School of the Environment, the Duke University Medical Center, and Trinity College of Arts and Sciences. We will link social, environmental, and genetic vulnerability using advanced spatial statistical approaches in combination with techniques from genetics and genomics. Using neural tube defects as a prototype health endpoint, we will develop a generalized framework for applying these methods to a wide variety of health endpoints, including autism, asthma, ADHD, and obesity.

描述（由申请人提供）： 尽管有新的共识，即许多疾病受到多种基因和基因环境相互作用的影响，但人们对遗传和环境因素如何相互作用以影响儿童的结果知之甚少。此外，尽管社会心理理论着重于社会经济特征如何影响儿童的健康状况，但我们几乎没有关于社会因素如何与遗传和环境因素相互作用以影响儿童幸福感的信息。因此，必须解决社会，环境和遗传因素的同时和综合影响的方法。杜克大学地理空间医学中心的任务是开发系统的，基于空间的方法，用于分析环境，遗传和社会心理领域共同塑造儿童健康和福祉的途径。该中心的具体目标是：1）建立一个跨学科中心，该中心支持脆弱性的遗传，环境和社会方面的研究，以影响儿童的健康和福祉； 2）促进生物医学，环境健康，统计和社会科学计划之间的跨学科研究互动； 3）推进将创新空间分析纳入健康研究的新方法； 4）开发新的和创造性的分析方法，以解决空间/时间变化，多重比较，混杂和效果修改； 5）培训年轻学者以由此产生的方法进行培训。我们将利用尼古拉斯环境学院，杜克大学医学中心和三一学院艺术与科学学院的积极伙伴关系。我们将使用先进的空间统计方法与遗传学和基因组学技术结合使用高级空间统计方法将社会，环境和遗传脆弱性联系起来。使用神经管缺陷作为原型健康终点，我们将开发一个通用框架，将这些方法应用于各种健康终点，包括自闭症，哮喘，ADHD和肥胖。