THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS

有袋动物胎儿母体耐受性的维持

• 批准号: 7171260
• 负责人: MICHELLE L BAKER
• 金额: $ 20.38万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171260
• 关键词: immunity; molecular genetics

DESCRIPTION (provided by applicant): A unique confluence of expertise in the areas of evolutionary/ comparative and theoretical immunobiology currently exists among the community of scholars working in New Mexico. The primary goal of this proposal is, through the opportunities provided by the COBRE program; establish a research center at the University of New Mexico with a thematic focus in these disciplines. The center will strengthen the ties among these senior investigators and so create a nurturing and vibrant environment where junior scholars with interests in theoretical and evolutionary immunobiology can prosper intellectually and become independently funded to pursue their interests in this area. This proposal builds on a tangible commitment made by the Department of Biology at UNM to strengthen this research area, and will foster increased connectivity with outstanding investigators with similar interests in University of New Mexico (UNM) Department of Computer Science and the Los Alamos National Laboratories (LANL). The Santa Fe Institute (SFI), located midway between UNM and LANL, has in the past fostered close ties between the mentors and will serve as a venue for many programmatic events. Evolutionary and theoretical aspects of immunology increasingly need to lie within the purview of the NIH. Indeed, there is a growing awareness of the great value of a solid theoretical basis for understanding how host defense systems work when confronted with infectious organisms or neoplasia. Also, our understanding of the important but neglected field of innate immunity, including human innate immunity, has been significantly advanced by discoveries made with fruit flies, pointing out the value of comparative models in illuminating the functions of mammalian immune systems. We seek to create an environment that regularly brings theoreticians and empiricists together, thus gaining new theoretical and historical perspectives on how immune systems evolve, and how sustainable and effective defense from pathogens is achieved. This program features four projects by outstanding and eligible investigators who are currently in place. It will also enable us to hire new faculty members to gain additional critical mass in these research areas, and provides urgently needed funds to strengthen the research infrastructure for our investigators. The research areas outlined are recognized by the scientific community as exciting and important. New Mexico has a growing reputation of leadership in these areas, and they present a novel opportunity to promulgate an ascendant field in which New Mexicans can define the cutting edge and that can not be easily duplicated anywhere else in the world.

描述(由申请人提供)： 目前，在新墨西哥州工作的学者群体中存在着进化/比较和理论免疫生物学领域的独特专业知识汇聚。这项提议的主要目标是，通过科布雷计划提供的机会，在新墨西哥大学建立一个研究中心，以这些学科为主题。该中心将加强这些高级研究人员之间的联系，从而创造一个培育和充满活力的环境，让对理论和进化免疫生物学感兴趣的初级学者可以在智力上蓬勃发展，并成为独立的资金，以追求他们在这一领域的兴趣。这项建议建立在新墨西哥大学生物系为加强这一研究领域所做的切实承诺的基础上，并将加强与新墨西哥大学(UNM)计算机科学系和洛斯阿拉莫斯国家实验室(LANL)具有相似兴趣的杰出研究人员的联系。圣达菲研究所(SFI)位于UNM和LANL之间，过去促进了导师之间的密切联系，并将成为许多方案活动的场所。免疫学的进化和理论方面越来越需要属于国家卫生研究院的职权范围。事实上，越来越多的人意识到，坚实的理论基础对于理解宿主防御系统在面对传染性生物或肿瘤时是如何工作的具有重大价值。此外，通过对果蝇的发现，我们对包括人类先天免疫在内的重要但被忽视的先天免疫领域的理解也得到了显著的提高，指出了比较模型在阐明哺乳动物免疫系统功能方面的价值。我们寻求创造一个定期将理论家和经验学家聚集在一起的环境，从而获得关于免疫系统如何进化以及如何实现对病原体的可持续和有效防御的新的理论和历史观点。该计划的特点是由目前已到位的优秀和合格的调查人员开展的四个项目。它还将使我们能够聘请新的教员，以在这些研究领域获得更多临界质量，并提供迫切需要的资金，以加强我们的研究人员的研究基础设施。科学界认为，概述的研究领域是令人兴奋和重要的。新墨西哥州在这些领域的领导地位越来越高，它们为宣布一个方兴未艾的领域提供了一个新的机会，在这个领域，新墨西哥州人可以定义尖端，世界其他任何地方都不能轻易复制。