THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS

有袋动物胎儿母体耐受性的维持

• 批准号: 7382029
• 负责人: MICHELLE L BAKER
• 金额: $ 10.15万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382029
• 关键词: MAINTENANCE; FETAL; MATERNAL; TOLERANCE; MARSUPIALS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of the remaining enigmas in immunology is the ability of the fetus to escape rejection by the maternal immune system despite antigenic differences in the embryo contributed by paternal alleles. It is clear from studies in placental mammals, humans in particular, that the maternal immune system is "aware" of the fetal antigens as foreign. How the maternal immune system is regulated to prevent rejection of fetal, specifically placental tissues, is not completely understood. A novel approach to understanding the problem of how fetal-maternal tolerance is maintained is to ask, "what mechanisms appeared during mammalian evolution to adapt the immune system to tolerate an allogeneic placenta?" This question can only be answered through comparative analysis of mammalian fetal-maternal interactions. In this proposal we are using marsupials as the alternative models of evolution of mammalian reproduction. Two species of marsupials are used in this study; the South American opossum, Monodelphis domestica, which has a simple yolk sac placenta and the Northern brown bandicoot, Isoodon macrourus, which has a chorio-allantoic placenta, not unlike eutherian mammals such as humans and mice. These two species should provide interesting insights into how different levels of placentation affect mechanisms of fetal-maternal tolerance. This study takes advantage of the NIH funded whole genome sequence of M. domestica.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。免疫学中剩余的谜团之一是胎儿能够逃避母体免疫系统排斥反应的能力，尽管胚胎在父亲等位基因造成的胚胎中存在抗原差异。从对胎盘哺乳动物，尤其是人类的研究可以清楚地看出，母体免疫系统“意识到”胎儿抗原是异物。未完全了解母体免疫系统以防止胎儿的排斥，特别是胎盘组织的排斥。一种新的方法来理解如何维持胎儿耐受性的问题是：“在哺乳动物进化过程中出现了哪些机制以适应免疫系统以耐受同种异体胎盘的耐受性？”这个问题只能通过对哺乳动物胎儿 - 母性相互作用的比较分析来回答。在此提案中，我们将有袋动物作为哺乳动物繁殖进化的替代模型。这项研究使用了两种有袋动物；南美负鼠单层家族有一个简单的蛋黄囊胎盘和北棕色的bandicoot，它具有合唱 - 甲烷烃胎盘，与人类和小鼠等Eutherian哺乳动物不同。这两个物种应提供有趣的见解，以了解不同水平的胎盘水平如何影响胎儿母性耐受性的机制。这项研究利用了NIH资助的全家基因组序列。