THE INTERFERON RESPONSE OF A MODEL CHIROPTERAN BAT; THE BLACK FLYING FOX, PTEROP

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 蝙蝠是各种病毒的天然宿主，其中许多病毒是人类、牲畜和伴侣动物严重疾病和死亡的原因。 虽然蝙蝠可能会持续感染许多病毒，但它们很少表现出临床症状。 因此，蝙蝠似乎能够与病毒共存，并且可能已经进化出快速控制病毒复制的机制，同时仍然允许传播和偶尔溢出到更易感的物种。 与蝙蝠耐受病毒的能力相反，最近发现的白色鼻综合征（WNS），一种导致美国东北部一些蝙蝠种群毁灭的真菌疾病，揭示了蝙蝠对真菌疾病的潜在易感性。 尽管由于WNS蝙蝠的破坏，以及它们在窝藏和传播病毒性疾病中的核心作用，但目前关于蝙蝠免疫系统的信息很少，并且很少有试剂可以研究蝙蝠的免疫反应。蝙蝠的免疫反应的信息将提供重要的见解蝙蝠如何逃避病毒感染的临床表现和原因，他们对WNS的易感性。 在这个建议中，我们使用的黑狐蝠，狐蝠作为一个模型来调查的作用，干扰素（IFN）的反应在蝙蝠的抗病毒免疫，以确定是否在IFN反应的差异有助于蝙蝠逃避病毒感染后的疾病的临床表现的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bats are natural host reservoirs for a variety of viruses, many of which are responsible for significant illness and mortality in humans, livestock and companion animals. Although bats may be persistently infected with many viruses, they rarely display clinical symptoms. Thus, bats appear to be able to co-exist with viruses and may have evolved mechanisms to rapidly control viral replication while still allowing transmission and occasional spillover to more susceptible species. In contrast to the ability of bats to tolerate viruses, the recent discovery of white nose syndrome (WNS), a fungal disease that has resulted in the devastation of some Northeastern US bat populations has revealed a potential susceptibility of bats to fungal diseases. Despite the devastation of bats due to WNS, and their central role in harboring and transmitting viral diseases, there is currently little information on the immune system of bats and few reagents exist to study the bat's immune response. Information on the immune response of bats would provide important insights into how bats escape the clinical manifestations of viral infection and the reasons for their susceptibility to WNS. In this proposal we are using the black flying fox, Pteropus alecto as a model to investigate the role of the interferon (IFN) response in antiviral immunity in bats to determine whether differences in the IFN response contribute to the ability of bats escape the clinical manifestations of disease following viral infection.