THE INTERFERON RESPONSE OF A MODEL CHIROPTERAN BAT; THE BLACK FLYING FOX, PTEROP

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 蝙蝠是各种病毒的天然宿主宿主，其中许多病毒对人类、牲畜和同伴动物的重大疾病和死亡负有责任。尽管蝙蝠可能会持续感染许多病毒，但它们很少出现临床症状。因此，蝙蝠似乎能够与病毒共存，并可能进化出快速控制病毒复制的机制，同时仍允许传播和偶尔溢出到更敏感的物种。与蝙蝠耐受病毒的能力相反，最近发现的白鼻症(WNS)，一种导致美国东北部一些蝙蝠种群遭到破坏的真菌疾病，揭示了蝙蝠对真菌疾病的潜在易感性。尽管WNS对蝙蝠造成了破坏，而且它们在窝藏和传播病毒疾病方面发挥了核心作用，但目前关于蝙蝠免疫系统的信息很少，研究蝙蝠免疫反应的试剂也很少。有关蝙蝠免疫反应的信息将为蝙蝠如何逃避病毒感染的临床表现以及它们对WNS易感性的原因提供重要的见解。在这项建议中，我们使用黑飞狐Pteropus Alecto作为模型来研究干扰素(IFN)反应在蝙蝠抗病毒免疫中的作用，以确定干扰素反应的差异是否有助于蝙蝠在病毒感染后逃避疾病的临床表现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bats are natural host reservoirs for a variety of viruses, many of which are responsible for significant illness and mortality in humans, livestock and companion animals. Although bats may be persistently infected with many viruses, they rarely display clinical symptoms. Thus, bats appear to be able to co-exist with viruses and may have evolved mechanisms to rapidly control viral replication while still allowing transmission and occasional spillover to more susceptible species. In contrast to the ability of bats to tolerate viruses, the recent discovery of white nose syndrome (WNS), a fungal disease that has resulted in the devastation of some Northeastern US bat populations has revealed a potential susceptibility of bats to fungal diseases. Despite the devastation of bats due to WNS, and their central role in harboring and transmitting viral diseases, there is currently little information on the immune system of bats and few reagents exist to study the bat's immune response. Information on the immune response of bats would provide important insights into how bats escape the clinical manifestations of viral infection and the reasons for their susceptibility to WNS. In this proposal we are using the black flying fox, Pteropus alecto as a model to investigate the role of the interferon (IFN) response in antiviral immunity in bats to determine whether differences in the IFN response contribute to the ability of bats escape the clinical manifestations of disease following viral infection.