THE INTERFERON RESPONSE OF A MODEL CHIROPTERAN BAT; THE BLACK FLYING FOX, PTEROP
翼手目蝙蝠模型的干扰素反应;
基本信息
- 批准号:8360211
- 负责人:
- 金额:$ 5.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:AntibodiesAntiviral AgentsAntiviral ResponseCell LineCellsCenters of Research ExcellenceChiropteraClinicalCoronavirusEvolutionFamily PteropodidaeFundingGene Expression ProfileGenesGenus PteropusGrantHenipavirusHumanImmuneImmune responseImmunityImmunologyInterferonsLivestockMammalsModelingMorbidity - disease rateNational Center for Research ResourcesNaturePrincipal InvestigatorRabies virusReagentResearchResearch InfrastructureResourcesSevere Acute Respiratory SyndromeSimuliidaeSourceUnited States National Institutes of HealthViralVirusVirus Diseasescompanion animalcostgene discoveryinsightmortalityresponse
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Bats are the natural host reservoir for a range of emerging and re-emerging viruses, including SARS-like Coronaviruses, Ebola, Henipaviruses and Rabies viruses. Many of the viruses carried by bats result in significant morbidity and mortality in humans, livestock and companion animals yet rarely result in clinical consequences in bats. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Our research seeks to understand the nature of antiviral immunity in bats using the model species, the Australian flying fox, Pteropus alecto. We are using a variety of approaches to examine the nature of innate and adaptive immune responses in bats including the characterization of genes known to be involved in antiviral immunity in other mammals and gene discovery using transcriptome analysis. We have also begun to investigate the expression of immune genes in virus infected cells and cell lines and develop bat specific antibody reagents. Understanding the antiviral responses of bats is crucial if we are to develop new treatments to control viral diseases in other mammals and will provide important insights into the evolution of antiviral immunity in mammals in general.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHELLE L BAKER其他文献
MICHELLE L BAKER的其他文献
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{{ truncateString('MICHELLE L BAKER', 18)}}的其他基金
SHINING A LIGHT ON BAT CELLULAR IMMUNITY FOLLOWING VIRUS INFECTION
揭示病毒感染后蝙蝠细胞免疫
- 批准号:
10449406 - 财政年份:2022
- 资助金额:
$ 5.94万 - 项目类别:
SHINING A LIGHT ON BAT CELLULAR IMMUNITY FOLLOWING VIRUS INFECTION
揭示病毒感染后蝙蝠细胞免疫
- 批准号:
10618969 - 财政年份:2022
- 资助金额:
$ 5.94万 - 项目类别:
THE INTERFERON RESPONSE OF A MODEL CHIROPTERAN BAT; THE BLACK FLYING FOX, PTEROP
翼手目蝙蝠模型的干扰素反应;
- 批准号:
8168271 - 财政年份:2010
- 资助金额:
$ 5.94万 - 项目类别:
THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS
有袋动物胎儿母体耐受性的维持
- 批准号:
7960516 - 财政年份:2009
- 资助金额:
$ 5.94万 - 项目类别:
THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS
有袋动物胎儿母体耐受性的维持
- 批准号:
7610561 - 财政年份:2007
- 资助金额:
$ 5.94万 - 项目类别:
THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS
有袋动物胎儿母体耐受性的维持
- 批准号:
7382029 - 财政年份:2006
- 资助金额:
$ 5.94万 - 项目类别:
THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS
有袋动物胎儿母体耐受性的维持
- 批准号:
7171260 - 财政年份:2005
- 资助金额:
$ 5.94万 - 项目类别:
THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS
有袋动物胎儿母体耐受性的维持
- 批准号:
6981926 - 财政年份:2004
- 资助金额:
$ 5.94万 - 项目类别:
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