Gene therapy to improve corneal graft survival

基因治疗可提高角膜移植物的存活率

• 批准号: nhmrc : 535000
• 负责人: A/Pr Sonja Klebe
• 金额: $ 34.28万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gene-therapy-improve-graft-survival/92324
• 关键词: Gene; therapy; improve; corneal; graft

The goal of our work is to improve outcomes for patients who are blind or seriously visually impaired as a result of corneal disease. Such patients can regain vision through a corneal transplant, but many such transplants fail. A corneal graft may fail because of an unwanted immune response, because blood vessels grow into the graft, or because some corneal cells die. We plan to transfer genes to the donor cornea in the laboratory, prior to corneal transplantation, to avoid such failure.

我们工作的目标是改善因角膜疾病而失明或严重视力受损的患者的预后。这些患者可以通过角膜移植恢复视力，但许多这样的移植失败。角膜移植可能会因为不必要的免疫反应而失败，因为血管生长到移植物中，或者因为一些角膜细胞死亡。我们计划在角膜移植之前，在实验室中将基因转移到供体角膜，以避免这种失败。